Magnesium aspartate

Magnesium aspartate (CAS 2068-80-6) is an amino acid-chelated magnesium salt; a bioavailable source of magnesium.

Where is Magnesium aspartate used?

• Dietary supplements and functional foods: tablets, capsules and powdered drink mixes for magnesium repletion
• Pharmaceuticals: active ingredient in electrolyte preparations and prescription magnesium therapy products
• Food and beverage: mineral fortifier in functional drinks and nutritional products
• Personal care: humectant and pH buffer in skin-conditioning products and topical preparations
• Its chelated form supports gastrointestinal tolerance compared to inorganic magnesium salts.

Good to know: Chelated form offers better gastrointestinal tolerance than inorganic magnesium salts. Food-grade and pharmaceutical-grade specifications include USP and Ph. Eur. grades.

Formulation notes

• For treatment and prevention of magnesium deficiency in adults, the oral dose is 10–20 mmol once daily, expressed as Mg2+.
• Magnesium preparations may not be interchangeable because of differences in bioavailability, so switching preparations requires caution to maintain tolerability and therapeutic effect.
• Bisphosphonates are poorly absorbed if taken without enough time before or after ingestion of supplements or medications containing high amounts of magnesium.
• Antibiotics may not be absorbed if taken without enough time before or after ingestion of a magnesium-containing dietary supplement.

Typical specification

• Assay is 98.0% to 102.0%.
• Water content of magnesium aspartate dihydrate is 10.0% to 16.0%.
• The pH of magnesium aspartate dihydrate is between 6.0 and 8.0.
• Total impurities are not more than 0.3%.
• A European Pharmacopoeia monograph exists for magnesium aspartate dihydrate.

Regulatory status

• The French medicines agency (ANSM) registers magnesium aspartate dihydrate as an active substance in its public substance database.
• Two pharmaceutical products marketed in France are identified as containing magnesium aspartate dihydrate.

Storage, packaging and handling

• It should be stored at ambient temperature, protected from moisture and light.

Frequently asked questions about Magnesium aspartate

How is magnesium aspartate standardized for consistent dosing?

It is standardized to 20% magnesium aspartate content for consistent dosing in supplement blends, food products and cosmetics.

Technical content is compiled and updated by the SoleChem product team from public technical sources; the certificate of analysis (COA) governs product-specific specifications.