Vitamin E Tocofersolan (TPGS)

Tocofersolan (CAS 9002-96-4) is a water-soluble form of vitamin E produced by esterifying natural vitamin E with polyethylene glycol 1000 succinate.

Where is Vitamin E Tocofersolan (TPGS) used?

• Pharmaceutical drug formulation: improves oral bioavailability of poorly water-soluble active ingredients, particularly BCS Class II and IV compounds
• Standard excipient in solid dispersions and self-emulsifying drug delivery systems
• Nutraceuticals: vitamin E supplements and pediatric formulations where water dispersibility is a critical product requirement
• Cosmetics and topical formulations: emulsifier and antioxidant stabilizer that extends the shelf life of oil-in-water emulsions
• Food-grade applications: nutrient carrier and emulsifying agent in fortified beverages and functional food products
• It functions as a solubilizer, emulsifier, and bioavailability enhancer.

Good to know: Pharmaceutical grade is the most commercially prevalent, with purity levels typically meeting compendial standards for use as a registered excipient.

Commercial specifications

• Purity levels typically meeting compendial standards