Tocofersolan

Tocofersolan (CAS 9002-96-4) is a water-soluble form of vitamin E produced by esterifying natural vitamin E with polyethylene glycol 1000 succinate. It functions as a solubilizer, emulsifier, and bioavailability enhancer across pharmaceutical, nutraceutical, and personal care manufacturing.

In pharmaceutical drug formulation, it is used to improve oral bioavailability of poorly water-soluble active ingredients, particularly BCS Class II and IV compounds. This makes it a standard excipient in solid dispersions and self-emulsifying drug delivery systems.

Nutraceutical manufacturers incorporate it into vitamin E supplements and pediatric formulations where water dispersibility is a critical product requirement. It ensures that fat-soluble nutrients can be effectively absorbed in aqueous environments.

In cosmetic and topical formulations, it functions as an emulsifier and antioxidant stabilizer, extending the shelf life of oil-in-water emulsions. Its dual functionality provides both structural stability and protective properties to high-end skincare products.

Food-grade applications include use as a nutrient carrier and emulsifying agent in fortified beverages and functional food products. It allows for the seamless integration of vitamins into clear liquids without affecting the visual clarity of the final product.

The material is supplied as a waxy solid or flake at ambient temperatures, transitioning to a viscous liquid when warmed. It is available in pharmaceutical-grade USP and Ph.Eur. specifications to meet global regulatory requirements.

Pharmaceutical grade is the most commercially prevalent, with purity levels typically meeting compendial standards for use as a registered excipient. This ensures consistent performance in sensitive drug delivery applications and large-scale manufacturing.