MeO-PEG-COOH (2 kDa)

MeO-PEG-COOH (2 kDa) is a methoxy-terminated polyethylene glycol bearing a terminal carboxylic acid group, with a nominal molecular weight of 2,000 Da. It functions as a reactive PEG linker used to conjugate, surface-modify, or solubilize active compounds.

This chemical, identified by CAS 92450-99-2, is essential in pharmaceutical and bioconjugation workflows. In drug delivery, it is used to PEGylate therapeutic proteins, peptides, and nanoparticles through carbodiimide-mediated coupling.

These processes extend circulation half-life and reduce immunogenicity in clinical applications. Lipid nanoparticle and liposome formulations incorporate it as a surface stabilizer to improve colloidal stability and control particle size.

In diagnostics and biosensor development, the carboxyl terminus enables covalent attachment to amine-functionalized surfaces, antibodies, or targeting ligands. This versatility makes it a staple for advanced medical research.

Personal care formulators use it as a carrier and solubilizing agent for active ingredients requiring controlled delivery or improved skin compatibility. It is supplied as a white to off-white powder or solid for easy handling.

The product is available in research and commercial quantities, with purity typically confirmed by NMR and GPC to verify molecular weight distribution and PDI. This ensures consistent performance across various industrial batches.

Pharmaceutical-grade material is offered with documentation supporting GMP-aligned workflows, including batch-specific certificates of analysis. We ensure all materials meet rigorous internal quality control protocols for safety.