MeO-PEG-COOH (2 kDa)

MeO-PEG-COOH (2 kDa) is a methoxy-terminated polyethylene glycol bearing a terminal carboxylic acid group, with a nominal molecular weight of 2,000 Da.

Where is MeO-PEG-COOH (2 kDa) used?

• Drug delivery: PEGylation of therapeutic proteins, peptides and nanoparticles via carbodiimide-mediated coupling, extending circulation half-life and reducing immunogenicity
• Lipid nanoparticle and liposome formulations: surface stabilizer for colloidal stability and particle size control
• Diagnostics and biosensors: covalent attachment to amine-functionalized surfaces, antibodies or targeting ligands
• Personal care: carrier and solubilizing agent for actives needing controlled delivery or improved skin compatibility
• It also serves as a reactive PEG linker to conjugate, surface-modify or solubilize active compounds.

Good to know: Purity is typically confirmed by NMR and GPC to verify molecular weight distribution and PDI. Pharmaceutical-grade material comes with documentation supporting GMP-aligned workflows, including batch-specific certificates of analysis.

Commercial specifications

• Nominal molecular weight 2,000 Da
• CAS 92450-99-2
• Research and commercial quantities
• Purity typically confirmed by NMR and GPC