Flavors & Fragrances
REACH
Anisole
CAS Number
100-66-3
EC Number
202-876-1
FEMA Number
FEMA 2097
What is Anisole?
Anisole (CAS 100-66-3), also known as phenyl methyl ether, is an aromatic ether used in fragrance, flavor, and specialty chemical manufacturing.
Where is Anisole used?
- Flavoring agent (FEMA 2097)
- Intermediate in synthesizing dyes, pharmaceuticals, and aroma chemicals
- Fragrance and flavor formulation: anise-like and sweet floral notes in perfumes and personal care products
- Dye and pigment manufacturing: intermediate for methoxy-substituted aromatic compounds in printing inks and packaging colorants
- Catalysis: solvent or substrate in Friedel-Crafts reactions and other electrophilic aromatic substitution processes
- It is a precursor in synthesizing active pharmaceutical and agrochemical ingredients.
Good to know: Technical grade is the standard commercial offering; food-grade and flavor-compliant material is available for FEMA-recognized sourcing documentation.
Commercial specifications
- Drum and IBC quantities
- Bulk tanker options for larger industrial volumes
Other Names (Synonyms)
phenyl methyl ether|methyl phenyl ether|Benzene, methoxy-|Anisol|Anizol|Phenol methyl ether
What are the physical properties of Anisole?
Melting Point -37.3 °C
Boiling Point 155.5 °C @ Press: 760 Torr
Density 0.9956 g/cm³ @ Temp: 18 °C
Flash Point 125 °F
Appearance Anisole is a colorless to yellowish liquid with an agreeable, aromatic, spicy-sweet odor.
Color Clear colorless
Odor phenol, anise odor
Form Liquid
Water Solubility 1.6 g/L (20 ºC)
Vapor Pressure 10 mm Hg ( 42.2 °C)
Refractive Index n 20/D 1.516(lit.)
Log P 2.62 at 30℃
How is Anisole classified and handled safely? Learn More
Warning
GHS02· Flammable GHS07· Irritant
Hazard Statements
H226 Flammable liquid and vapor
H315 Causes skin irritation
H319 Causes serious eye irritation
H336 May cause drowsiness or dizziness
Precautionary Statements
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment.
Which trade and regulatory codes apply to Anisole?
HS Code 29093000
UN Number 2222
ADR Class 3
Packing Group III
Storage Class 3 - Flammable liquids
WGK (Germany) 2