Vitamins
REACH
Vitamin K1 Phylloquinone
CAS Number
84-80-0
EC Number
201-564-2
Chemical Formula
C31H46O2
Molecular Weight
450.7 g/mol
Form
oil
Grade
FCC, USP, BP, food
What is Vitamin K1 Phylloquinone?
Phylloquinone (CAS 84-80-0), commercially recognized as Vitamin K1, is the naturally occurring form of vitamin K derived primarily from plant sources.
Where is Vitamin K1 Phylloquinone used?
- Food and infant formula: fortification to meet regulatory nutrient reference values
- Pharmaceuticals: injectable solutions, oral capsules, and tablets for vitamin K deficiency and anticoagulant reversal
- Cosmetics: eye creams, serums, and post-procedure skincare for dark circles and bruising
- Clinical nutrition: parenteral and enteral products requiring complete micronutrient profiles
- It functions as a bioactive nutrient in food fortification and pharmaceutical formulations.
Commercial specifications
- Emulsified and water-dispersible formats for aqueous systems
- Grades: USP, BP, Ph. Eur.
Other Names (Synonyms)
Phylloquinone|Vitamin K1|Vitamin k|trans-Phylloquinone|Synthex P|Phythyl-menadion|Monodion|Mono-Kay|Mephyton
What are the physical properties of Vitamin K1 Phylloquinone?
Melting Point -20 °C
Boiling Point 140-145 °C @ Press: 1 x 10-3 Torr
Density 0.964 g/cm³ @ Temp: 25 °C
Flash Point >230 °F
Appearance Phylloquinone is an odorless yellow viscous oil or crystals.
Color Yellow to Dark Yellow
Odor odorless
Form viscous liquid
Water Solubility Miscible with dehydrated alcohol, acetone, petroleum ether, hexane, dioxane, chloroform, ether, benzene and vegetable oils. Immiscible with water.
Refractive Index n 20/D 1.527(lit.)
Log P 10.305 (est)
How is Vitamin K1 Phylloquinone classified and handled safely? Learn More
Warning
GHS07· Irritant
Hazard Statements
H317 May cause an allergic skin reaction
H413 May cause long lasting harmful effects to aquatic life
Precautionary Statements
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
Which trade and regulatory codes apply to Vitamin K1 Phylloquinone?
HS Code 29369000
UN Number 1170
Packing Group II
Storage Class 10 - Combustible liquids
WGK (Germany) 2