2-chloro-5-methoxyaniline

2-Chloro-5-methoxyaniline (CAS 2401-24-3), also known commercially as 6-chloro-m-anisidine, is an aromatic amine intermediate used in the synthesis of active pharmaceutical ingredients and specialty agrochemicals.

Where is 2-chloro-5-methoxyaniline used?

• Pharmaceutical synthesis: key starting material for drug candidates, particularly kinase inhibitors and other small-molecule therapeutics requiring precise substitution patterns
• Agrochemicals: production of herbicide and fungicide active ingredients, with chloro and methoxy groups directing selective reactivity during coupling steps
• Dyes and pigments: azo dye synthesis, where the aniline nitrogen undergoes diazotization to generate stable colorant intermediates for textile and industrial coatings
• Polymer research: co-monomer or initiator component in specialty polymerization systems
• Its dual functional groups, a reactive amine and a chloro substituent, make it a building block for complex heterocyclic and azo-based target molecules.

Commercial specifications

• Technical grade for industrial synthesis; higher-purity grades for pharmaceutical intermediate applications
• Packaging from small research quantities to bulk drum supply