Amines
REACH
2-amino-5-chlorobenzotrifluoride
CAS Number
445-03-4
EC Number
207-151-3
What is 2-amino-5-chlorobenzotrifluoride?
2-Amino-5-chlorobenzotrifluoride (CAS 445-03-4), also known as 2-Trifluoromethyl-4-chloroaniline, is an aromatic amine intermediate built around a trifluoromethyl group and a reactive primary amine.
Where is 2-amino-5-chlorobenzotrifluoride used?
- Pharmaceutical manufacturing: building block for drug candidates and APIs
- Agrochemical synthesis: fluorinated aniline scaffolds for herbicide and fungicide active substances
- Dye and pigment production: coupling component or precursor in azo colorants for textile and paper
- Personal care and cosmetic preservation: biocidal profile supports use in formulations
- The trifluoromethyl group improves metabolic stability and membrane permeability.
Commercial specifications
- Technical and high-purity grades for pharmaceutical intermediate and fine chemical manufacturing
- Packaging from small laboratory quantities to bulk drums
Other Names (Synonyms)
4-Chloro-alpha,alpha,alpha-trifluoro-o-toluidine|Benzenamine, 4-chloro-2-(trifluoromethyl)-|2-Trifluoromethyl-4-chloroaniline|RefChem:561881|4-Chloro-2-(trifluoromethyl)aniline|o-Toluidine, 4-chloro-α,α,α-trifluoro-|4-Chloro-2-(trifluoromethyl)benzenamine|C.I. 37055
What are the physical properties of 2-amino-5-chlorobenzotrifluoride?
Melting Point 8.8 °C
Boiling Point 76-78 °C @ Press: 4-5 Torr
Density 1.386 g/mL at 25 °C(lit.)
Flash Point 203 °F
Appearance Clear yellow liquid
Color Colorless to Orange to Green
Form clear liquid
Vapor Pressure 48.5-1013hPa at 110.5-208.2℃
Refractive Index n 20/D 1.507(lit.)
pH 7.4 at 20℃ and 995mg/L
Log P 2.68
How is 2-amino-5-chlorobenzotrifluoride classified and handled safely? Learn More
Warning
GHS07· Irritant GHS08· Health Hazard
Hazard Statements
H302 Harmful if swallowed
H312 Harmful in contact with skin
H315 Causes skin irritation
H319 Causes serious eye irritation
Precautionary Statements
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Which trade and regulatory codes apply to 2-amino-5-chlorobenzotrifluoride?
HS Code 29214300
UN Number 2810
Storage Class 10 - Combustible liquids
WGK (Germany) 2