Trifluoroacetic anhydride

Trifluoroacetic anhydride (CAS 407-25-0), commonly abbreviated as TFAA, is a highly reactive acylating agent.

Where is Trifluoroacetic anhydride used?

• Pharmaceutical and agrochemical synthesis: introduces trifluoroacetyl groups to amines, alcohols, and other nucleophiles, supporting the production of APIs and intermediates
• Polymer and specialty materials: modifies surface properties and introduces fluorine content into polymer backbones, improving thermal stability and flame retardant performance
• Textile and leather processing: surface modification and preservation chemistry
• Printing and packaging: preparation of specialty coatings and functional additives
• It activates and protects functional groups in complex organic molecules.

Commercial specifications

• Purity levels commonly at 99% or higher for synthesis-critical applications
• Packaging from small laboratory quantities to bulk drums