Organic Acids
REACH
Trifluoroacetic acid
CAS Number
76-05-1
EC Number
200-929-3
Abbreviation
TFA
What is Trifluoroacetic acid?
Trifluoroacetic acid (CAS 76-05-1), commonly abbreviated as TFA, is a strong fluorinated organic acid.
Where is Trifluoroacetic acid used?
- Pharmaceutical manufacturing: standard reagent for Boc-group removal in API production
- Analytical laboratories: HPLC mobile phase additive that improves peak resolution and retention of basic compounds
- Textile and leather processing: pH regulation and catalyst in dyeing and finishing baths
- Specialty chemicals: solvent and activating agent in synthesis of fluorinated intermediates and agrochemicals
- It functions as a reaction catalyst, ion-pairing reagent, and deprotection agent.
Commercial specifications
- 99%+ purity for pharmaceutical and analytical applications
- HPLC-grade held to strict UV transparency and water content limits
- Bulk quantities and smaller packaging formats for laboratory procurement
Other Names (Synonyms)
perfluoroacetic acid|2,2,2-trifluoroacetic acid|TFA|Trifluoracetic acid|Trifluoroethanoic acid|Acetic acid, trifluoro-|Kyselina trifluoroctova|Acetic acid, 2,2,2-trifluoro-
What are the physical properties of Trifluoroacetic acid?
Melting Point -15.2 °C
Boiling Point 72.4 °C
Density 1.49 g/cm³ (liquid) @ Temp: 25 °C
Flash Point None
Appearance Colorless, fuming liquid; hygroscopic; pungent odor. Very soluble in water. Nonflammable.
Color Colorless
Odor Sharp, pungent odor
Form Liquid
Water Solubility miscible
Vapor Pressure 97.5 mm Hg ( 20 °C)
Refractive Index n 20/D 1.3(lit.)
pH 1 (10g/l, H2O)
How is Trifluoroacetic acid classified and handled safely? Learn More
Danger
GHS05· Corrosive GHS07· Irritant GHS06· Toxic
Hazard Statements
H290 May be corrosive to metals
H301 Toxic if swallowed
H302 Harmful if swallowed
H314 Causes severe skin burns and eye damage
Precautionary Statements
P234 Keep only in original packaging.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
Which trade and regulatory codes apply to Trifluoroacetic acid?
HS Code 29159080
UN Number 2699
ADR Class 8
Packing Group I
Storage Class 8A - Combustible corrosive hazardous materials
WGK (Germany) 2