Solvents
REACH
tert-butyl acetate
CAS Number
540-88-5
EC Number
208-760-7
Abbreviation
TBAc
What is tert-butyl acetate?
Tert-butyl acetate (CAS 540-88-5), commonly abbreviated as TBAc, is a slow-evaporating ester solvent.
Where is tert-butyl acetate used?
- Pharmaceutical manufacturing: reaction solvent and intermediate in peptide synthesis and API processing
- Coatings and inks: carrier solvent improving flow, leveling and film formation in high-solids systems
- Fragrance compounding: clean, fruity character
- Flavor formulations: mild, apple-like ester note at low use levels
- It also appears in fine fragrance and personal care applications.
Good to know: Low HAP classification under U.S. EPA regulations makes it an alternative to conventional ketone and aromatic solvents in regulated production environments. Buyers should confirm solvent residual class compliance; for regulated pharmaceutical use, verify EP or Ph. Eur. standards.
Commercial specifications
- Clear liquid in drum and IBC quantities; bulk tanker options for high-volume buyers
- Standard commercial grades meet technical specifications
- Pharmaceutical-grade material meets USP and BP requirements for API and drug product applications
Other Names (Synonyms)
tert-butyl ester of acetic acid|t-butyl acetate|Acetic acid, 1,1-dimethylethyl ester|Texaco lead appreciator|Acetic acid, tert-butyl ester|1,1-Dimethyl acetate|76N22HKP3X|TBAc
What are the physical properties of tert-butyl acetate?
Melting Point <25 °C
Boiling Point 97.8 °C
Density 0.8593 g/cm³ @ Temp: 25 °C
Flash Point 60 °F
Appearance Butyl acetates are colorless or yellowish liquids with pleasant, fruity odors. There are 4 isomers.
Color Clear colorless
Odor Fruity
Form Liquid
Water Solubility insoluble
Vapor Pressure 41 hPa (20 °C)
Refractive Index n 20/D 1.386(lit.)
Log P 1.64 at 21.7℃
How is tert-butyl acetate classified and handled safely? Learn More
Danger
GHS02· Flammable GHS07· Irritant
Hazard Statements
H225 Highly Flammable liquid and vapor
H320 Causes eye irritation
H332 Harmful if inhaled
H335 May cause respiratory irritation
H336 May cause drowsiness or dizziness
Precautionary Statements
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment.
Which trade and regulatory codes apply to tert-butyl acetate?
HS Code 29153990
UN Number 1123
ADR Class 3
Packing Group II
Storage Class 3 - Flammable liquids
WGK (Germany) 1