tert-butyl acetate

Tert-butyl acetate (CAS 540-88-5), commonly abbreviated as TBAc, is a slow-evaporating ester solvent used across pharmaceutical synthesis, coatings, and specialty chemical manufacturing. Its low HAP classification under U.S. EPA regulations makes it a preferred alternative to conventional ketone and aromatic solvents in regulated production environments.

In pharmaceutical manufacturing, TBAc functions as a reaction solvent and intermediate in peptide synthesis and API processing, where controlled evaporation rates support yield and purity targets. Coatings and ink formulators use it as a carrier solvent to improve flow, leveling, and film formation in high-solids systems. In fragrance compounding, TBAc contributes a clean, fruity character.

This material is suitable for fine fragrance and personal care applications. It also appears in flavor formulations where a mild, apple-like ester note is required at low use levels. TBAc is supplied as a clear liquid in drum and IBC quantities, with bulk tanker options available for high-volume industrial buyers. Standard commercial grades meet technical specifications.

Pharmaceutical-grade material is available to meet USP and BP requirements for API and drug product applications. Buyers should confirm solvent residual class compliance. When sourcing for regulated pharmaceutical use, ensure the material meets EP or Ph.Eur. standards. This ensures the highest level of safety and performance in your manufacturing process.