Tetrabutylurea

Tetrabutylurea (CAS 4559-86-8), commonly abbreviated as TBU, is a high-boiling polar aprotic solvent.

Where is Tetrabutylurea used?

• Pharmaceutical synthesis: process solvent
• Biotechnology: solubilizing carrier for difficult-to-dissolve compounds
• Industrial and institutional cleaning: dissolves stubborn organic residues and polymer deposits
• High-temperature coating and specialty chemical processes: suited to high boiling point
• It functions as a carrier and reaction medium where conventional solvents fall short in thermal stability or solvating power.

Good to know: Buyers sourcing for pharmaceutical or biotech use should confirm GMP-aligned documentation with their suppliers. Batch-level analytical data should be reviewed to ensure the material meets the necessary requirements.

Commercial specifications

• Purity specifications typically at 98% or above for synthesis-grade applications
• Technical and high-purity grades
• Clear liquid in standard drum and IBC packaging suited for industrial volumes
• Solvent retention and stability are critical procurement considerations