Acetyl chloride
CAS Number
75-36-5
EC Number
200-865-6
What is Acetyl chloride?
Acetyl chloride (CAS 75-36-5), also known as acetic chloride, is a highly reactive acylating agent used in pharmaceutical synthesis and specialty chemical manufacturing.
Where is Acetyl chloride used?
- Pharmaceutical manufacturing: acetylates amines, alcohols and phenols to produce APIs and protected intermediates
- Cosmetic ingredient synthesis: produces acetylated derivatives
- Modifies fatty alcohols and other actives to improve stability or skin-feel
- Catalyst activator and reagent in the preparation of anhydrides and other acylating agents
- Contract manufacturers and formulators processing complex multi-step syntheses source it as a key reagent.
Good to know: High purity and consistent reactivity directly affect yield. Packaging configurations are selected to maintain anhydrous conditions throughout storage and transport to prevent degradation.
Commercial specifications
- Purity specifications commonly at 98% and above
- Typically in drums or ISO tanks suited for moisture-sensitive materials
- Technical and high-purity reagent grades
Other Names (Synonyms)
ethanoyl chloride|CH3COCl|acetic chloride|acetic acid chloride|QD15RNO45K
What are the physical properties of Acetyl chloride?
Melting Point -112 °C
Boiling Point 52 °C
Density 1.1051 g/cm³ @ Temp: 20 °C
Flash Point 40 °F
Appearance Acetyl chloride is a highly flammable, colorless, fuming liquid with a pungent odor
Color Clear colorless
Odor Strong pungent odor
Form Liquid
Water Solubility Decomposes violently in water
Vapor Pressure 11.69 psi ( 20 °C)
Refractive Index n 20/D 1.389(lit.)
How is Acetyl chloride classified and handled safely? Learn More
Danger
GHS02· Flammable GHS05· Corrosive GHS07· Irritant
Hazard Statements
H225 Highly Flammable liquid and vapor
H290 May be corrosive to metals
H302 Harmful if swallowed
H314 Causes severe skin burns and eye damage
Precautionary Statements
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P234 Keep only in original packaging.
P240 Ground and bond container and receiving equipment.
Which trade and regulatory codes apply to Acetyl chloride?
HS Code 29159080
UN Number 1717
ADR Class 3
Packing Group II
Storage Class 3 - Flammable liquids
WGK (Germany) 1