Benzoyl chloride

CAS Number
98-88-4
EC Number
202-710-8

What is Benzoyl chloride?

Benzoyl chloride (CAS 98-88-4) is a high-reactivity acylating agent used in pharmaceutical synthesis, agrochemical manufacturing, and specialty chemical production.

Where is Benzoyl chloride used?

  • Pharmaceutical manufacturing: key intermediate in the synthesis of active ingredients, including analgesics, antimicrobials, and UV-absorbing compounds used in topical formulations
  • Cosmetics: production of benzoate esters and benzoyl peroxide precursors
  • Dyes, resins, and agrochemical intermediates: controlled benzoylation for specific chemical reactions
  • Laboratory and biotech: derivatizing agent for analytical workflows, enabling detection and characterization of alcohols and amines
  • It introduces the benzoyl group into target molecules, enabling the construction of esters, amides, and anhydrides at industrial scale.

Good to know: Buyers sourcing for pharmaceutical applications should confirm compliance with relevant pharmacopoeial or GMP documentation requirements for their supply chain.

Commercial specifications

  • Purity specifications typically range from 98% to 99% or higher depending on the specific grade required.
  • Standard quality benchmarks often include USP, BP, or EP standards depending on the region of use.

Other Names (Synonyms)

Benzenecarbonyl chloride|Benzoic acid, chloride|alpha-Chlorobenzaldehyde|Benzaldehyde, alpha-chloro-|VTY8706W36|Benzaldehyde, α-chloro-|Phenylcarbonyl chloride

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What are the physical properties of Benzoyl chloride?

Melting Point -1.0 °C
Boiling Point 197.2 °C @ Press: 760 Torr
Density 1.2070 g/cm³ @ Temp: 25 °C
Flash Point 156 °F
Appearance Benzoyl chloride is a colorless to slight brown liquid with a strong, penetrating odor.
Color Clear
Odor Pungent characteristic.
Form Liquid
Water Solubility reacts
Vapor Pressure 1 mm Hg ( 32 °C)
Refractive Index n 20/D 1.553(lit.)
pH 2 (1g/l, H2O, 20℃)
Log P 1.44 at 21℃ and pH6

How is Benzoyl chloride classified and handled safely? Learn More

Danger
GHS05· Corrosive GHS07· Irritant GHS06· Toxic GHS08· Health Hazard GHS09· Environmental Hazard

Hazard Statements

H227 Combustible liquid
H302 Harmful if swallowed
H311 Toxic in contact with skin
H312 Harmful in contact with skin

Precautionary Statements

P203 Obtain, consult and follow expert instructions for use.
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

Which trade and regulatory codes apply to Benzoyl chloride?

HS Code 29310095
UN Number 1736
ADR Class 8
Packing Group II
Storage Class 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
WGK (Germany) 1
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