2,2-dimethylbutyryl chloride

2,2-Dimethylbutyryl chloride (CAS 5856-77-9) is a reactive acyl chloride used as a building block in organic synthesis and pharmaceutical manufacturing.

Where is 2,2-dimethylbutyryl chloride used?

• Organic synthesis: introduces the 2,2-dimethylbutanoyl group into target molecules through acylation
• Pharmaceutical synthesis: acylates amines, alcohols and other nucleophiles to produce protected intermediates and API precursors
• Fragrance and flavour: ester and amide derivatives with branched-chain profiles for fine fragrance and aroma formulations
• Biotechnology and life sciences: prodrugs, enzyme substrates and biochemical probes
• Catalyst precursor component in select organometallic and coordination chemistry applications
• It enables the construction of complex intermediates with defined steric profiles.

Good to know: Particularly useful where steric bulk at the alpha-carbon is required. Applications often require controlled lipophilicity and hydrolytic stability as primary design criteria.

Commercial specifications

• Purity specifications commonly range from 95% to 98%+ depending on the intended synthetic use and specific customer requirements.
• Small research quantities through to multi-kilogram lots for process-scale applications.