Pivaloyl chloride
CAS Number
3282-30-2
EC Number
221-921-6
What is Pivaloyl chloride?
Pivaloyl chloride (CAS 3282-30-2), also known as trimethylacetyl chloride, is a reactive acylating agent.
Where is Pivaloyl chloride used?
- Pharmaceutical manufacturing: activates amino acids and carboxylic acids to form mixed anhydrides
- Agrochemicals: manufacture of herbicide and pesticide esters, where the bulky pivaloyl group improves hydrolytic stability
- Polymerization: catalyst precursor in Ziegler-Natta systems
- Contract synthesis and fine chemical operations: acylation steps in multi-stage routes to complex intermediates
- It introduces the pivaloyl protecting group or activates carboxylic acid derivatives for downstream coupling reactions.
Good to know: Sensitive to hydrolysis during storage and transit; buyers should confirm moisture-controlled packaging requirements.
Commercial specifications
- Purity specifications typically 98% or higher for industrial use
- Liquid in standard packaging from small laboratory quantities to bulk drums
Other Names (Synonyms)
2,2-Dimethylpropanoyl chloride|Trimethylacetyl chloride|Propanoyl chloride, 2,2-dimethyl-|Pivalyl chloride|2,2-Dimethylpropionyl chloride|Pivalolyl chloride|Pivalic acid chloride|Neopentanoyl chloride
What are the physical properties of Pivaloyl chloride?
Melting Point -56 °C
Boiling Point 102-104 °C
Density 0.9798 g/cm³ @ Temp: 20 °C
Flash Point 48 °F
Appearance Colorless to yellow liquid
Color Clear almost colorless to light pink
Form Liquid
Water Solubility Hydrolysis
Vapor Pressure 36 mm Hg ( 20 °C)
Refractive Index n 20/D 1.412(lit.)
Log P 1.680 (est)
How is Pivaloyl chloride classified and handled safely? Learn More
Danger
GHS02· Flammable GHS05· Corrosive GHS06· Toxic GHS07· Irritant GHS08· Health Hazard
Hazard Statements
H225 Highly Flammable liquid and vapor
H290 May be corrosive to metals
H302 Harmful if swallowed
H314 Causes severe skin burns and eye damage
Precautionary Statements
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P234 Keep only in original packaging.
P240 Ground and bond container and receiving equipment.
Which trade and regulatory codes apply to Pivaloyl chloride?
HS Code 29159080
UN Number 2438
ADR Class 6.1
Packing Group I
Storage Class 3 - Flammable liquids
WGK (Germany) 1