Cholesteryl chloride

Cholesteryl chloride (CAS 910-31-6), also known as cholesterol chloride and 3-chlorocholest-5-ene, is a reactive cholesterol derivative used as a synthetic building block in pharmaceutical and biotechnology research.

Where is Cholesteryl chloride used?

• Pharmaceutical development: synthesis of cholesterol-conjugated compounds, including prodrugs and lipid-based drug delivery systems for membrane permeability and cellular uptake
• Biotechnology: preparation of cholesterol-tagged oligonucleotides and siRNA conjugates, where cholesterol attachment enhances in vivo stability and tissue targeting
• Intermediate for steroid derivatives and cholesterol esters used as reference standards and analytical reagents in QC workflows
• Specialty lipid formulators introduce cholesterol anchors into liposomal and nanoparticle systems under development.

Commercial specifications

• Purity grades typically 95% to 98%+ by GC or HPLC
• Packaging in gram to kilogram quantities under inert atmosphere