Tert-butyldimethylsilyl chloride

Tert-butyldimethylsilyl chloride (CAS 18162-48-6), commonly referenced as TBDMSCl, is a silylating reagent used to introduce the TBDMS protecting group onto hydroxyl, carboxyl, and amine functionalities.

Where is Tert-butyldimethylsilyl chloride used?

• Pharmaceutical synthesis and research chemistry: selective protection of reactive sites during multi-step synthesis sequences
• Active pharmaceutical ingredient manufacturing: protection of alcohol and hydroxyl groups
• Nucleoside and nucleotide synthesis: TBDMS protection to control regioselectivity
• Electronics and semiconductor fabrication: modification of silicon wafer surfaces and resists to control hydrophobicity and adhesion
• Biotechnology: solid-phase synthesis of oligonucleotides
• Precise protecting group chemistry directly determines final product purity and overall yield.

Good to know: Moisture-controlled packaging is standard due to its reactivity with atmospheric humidity.

Commercial specifications

• Reagent-grade and high-purity grades
• Purity specifications typically at 97–99%+
• Packaging ranges from laboratory-scale quantities to multi-kilogram industrial lots