tert-butyl n-hydroxycarbamate

Tert-butyl n-hydroxycarbamate (CAS 36016-38-3), also marketed as N-Boc-hydroxylamine, is a protected hydroxylamine reagent used in pharmaceutical synthesis and specialty chemical manufacturing.

Where is tert-butyl n-hydroxycarbamate used?

• Pharmaceutical intermediates: building block for isoxazolines, hydroxyurea derivatives and other nitrogen-containing scaffolds in active pharmaceutical ingredients
• Medicinal chemistry: installs protected hydroxylamine groups in multi-step synthesis, with the Boc group removed under standard acidic conditions at a late stage
• Catalyst development: precursor to nitroxide-based and N-oxyl catalysts for oxidation reactions
• It provides a stable, handleable form of hydroxylamine functionality, enabling controlled introduction of the N–OH group without the hazards of free hydroxylamine.

Good to know: It provides a stable, handleable form of hydroxylamine functionality, enabling controlled introduction of the N–OH group without the hazards associated with free hydroxylamine.

Commercial specifications

• Purity grades typically 97% to 99%+, confirmed by HPLC or titration
• Research quantities through to multi-kilogram commercial lots
• Documentation packages including CoA
• Spectral data standard for GMP-adjacent procurement