di-tert-butyl dicarbonate
CAS Number
24424-99-5
EC Number
246-240-1
Abbreviation
Boc₂O
Industries: Pharma & Healthcare
What is di-tert-butyl dicarbonate?
Di-tert-butyl dicarbonate (CAS 24424-99-5), commonly known as Boc₂O or BOC-anhydride, is a reagent used in pharmaceutical synthesis and biotechnology to introduce the tert-butoxycarbonyl protecting group onto amines.
Where is di-tert-butyl dicarbonate used?
- Pharmaceutical manufacturing: protects amine groups during multi-step synthesis of active pharmaceutical ingredients, preventing unwanted side reactions
- Peptide synthesis: Boc chemistry in solid-phase and solution-phase processes producing therapeutic peptides and amino acid derivatives
- Biotechnology: modifies proteins, linkers and bioconjugates where reversible amine protection is required
- Agrochemical and specialty chemical synthesis: clean transformations
- It is central to controlled peptide assembly and API manufacturing.
Commercial specifications
- Reagent-grade and high-purity pharmaceutical-grade specifications suited to GMP manufacturing environments
- Packaging from laboratory quantities up to drum-scale supply
Other Names (Synonyms)
Boc₂O|BOC-anhydride|bis(tert-butoxycarbonyl)oxide|Di(tert-butyl) carbonate|di-tert-Butyl pyrocarbonate|Boc2O|Dicarbonic acid, bis(1,1-dimethylethyl) ester|Z10Q236C3G
What are the physical properties of di-tert-butyl dicarbonate?
Melting Point 22-24 °C
Boiling Point 65-66 °C @ Press: 1 Torr
Density 0.95 g/mL at 25 °C(lit.)
Flash Point 99 °F
Appearance White to off-white microcrystalline powder
Color White
Form Low Melting Crystalline Solid
Water Solubility Miscible with decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile and dimethylformamide. Immiscible with water.
Vapor Pressure 3.85Pa at 25℃
Refractive Index n 20/D 1.409(lit.)
Log P 1.87 at 25℃
How is di-tert-butyl dicarbonate classified and handled safely? Learn More
Danger
GHS02· Flammable GHS05· Corrosive GHS06· Toxic GHS07· Irritant
Hazard Statements
H225 Highly Flammable liquid and vapor
H226 Flammable liquid and vapor
H228 Flammable solid
H315 Causes skin irritation
Precautionary Statements
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment.
Which trade and regulatory codes apply to di-tert-butyl dicarbonate?
HS Code 29209010
UN Number 2929
ADR Class 6.1
Packing Group I
Storage Class 3 - Flammable liquids
WGK (Germany) 3