Tetramethylammonium chloride

Tetramethylammonium chloride (CAS 75-57-0), commonly abbreviated as TMAC, is a quaternary ammonium salt used as a phase-transfer catalyst and reagent.

Where is Tetramethylammonium chloride used?

• Pharmaceutical synthesis: phase-transfer catalyst facilitating alkylation
• Nucleophilic substitution reactions and production of active pharmaceutical ingredients
• Biotechnology: DNA hybridization assays, equalizing melting temperatures and stabilizing AT- and GC-rich sequences to improve probe specificity
• Polymer and plastics manufacturing: catalyst or catalyst precursor in polymerization
• Epoxy resins and specialty polymers
• Nitrogen source and templating agent in synthesis of zeolites and other porous materials
• It enables reactions between compounds in incompatible phases, improving yields and reducing processing complexity.

Commercial specifications

• High-purity grades meeting reagent or analytical specifications for pharmaceutical and life sciences use
• Packaging from laboratory-scale quantities to bulk industrial supply