1,1,3,3-Tetramethylguanidine

1,1,3,3-Tetramethylguanidine (CAS 80-70-6), commonly known as TMG, is a strong, non-nucleophilic organic superbase used as a catalyst and proton acceptor.

Where is 1,1,3,3-Tetramethylguanidine used?

• Polyurethane and epoxy: accelerates cure by activating isocyanate or epoxide crosslinking
• Adhesives and sealants: promotes room-temperature curing in silicone and polyurethane systems
• Coatings: neutralizing agent for acid-functional resins, improving dispersion stability and film formation
• Polymer production: base catalyst in ring-opening polymerizations and condensation reactions
• It tunes gel times and processing windows.

Good to know: High basicity without nucleophilic interference suits processes where conventional amine catalysts cause unwanted side reactions. Specification requirements should be confirmed with the supplier, as purity thresholds vary by end-use process sensitivity.

Commercial specifications

• Technical grade, purity typically 99% or higher for catalyst-grade applications
• Standard drum and IBC quantities