Amines
REACH
N,n,n',n'-tetramethylethylenediamine
CAS Number
110-18-9
EC Number
203-744-6
Abbreviation
TMEDA
What is N,n,n',n'-tetramethylethylenediamine?
N,N,N',N'-Tetramethylethylenediamine (CAS 110-18-9), also known as TMEDA or TEMED, is a chelating diamine used as a ligand and catalyst activator in organometallic chemistry, polymer production and life sciences.
Where is N,n,n',n'-tetramethylethylenediamine used?
- Organolithium chemistry: activates n-BuLi and similar reagents by breaking aggregates
- Pharmaceutical intermediates: improved reaction selectivity
- Polymer production: accelerator in acrylamide gel polymerization, notably PAGE gel systems for electrophoresis in biotech and diagnostic workflows
- Coordination chemistry and catalyst preparation: bidentate ligand that stabilizes metal complexes for polymerization and fine chemical production
- Specialty resins and rubber: tertiary amine catalyst that drives urethane and epoxy cure reactions
- It coordinates strongly with metal ions and alkyllithium reagents, enabling controlled reactivity.
Commercial specifications
- 99%+ purity for synthesis-grade applications
- Electrophoresis-grade material meets tighter purity requirements of diagnostic end users
- Bulk quantities in drums and IBCs; smaller packaging for laboratory and pharmaceutical procurement
Other Names (Synonyms)
TMEDA|TEMED|N,N,N',N'-tetramethylethane-1,2-diamine|1,2-Bis(dimethylamino)ethane|Propamine D|Tetrameen|1,2-Ethanediamine, N1,N1,N2,N2-tetramethyl-|Ethylenediamine, N,N,N′,N′-tetramethyl-
What are the physical properties of N,n,n',n'-tetramethylethylenediamine?
Melting Point -55 °C
Boiling Point 121 °C
Density 0.7765 g/cm³ @ Temp: 20 °C
Flash Point 50 °F
Appearance Colorless to slightly yellow liquid
Color Clear colorless to slightly yellow
Odor Amine like
Form Liquid
Water Solubility miscible
Vapor Pressure 21 hPa (20 °C)
Refractive Index n 20/D 1.4179(lit.)
pH 8.0-8.5 (0.1g/l, H2O, 20℃)
Log P -0.13 at 20.2℃
How is N,n,n',n'-tetramethylethylenediamine classified and handled safely? Learn More
Danger
GHS02· Flammable GHS05· Corrosive GHS07· Irritant GHS06· Toxic GHS09· Environmental Hazard GHS08· Health Hazard
Hazard Statements
H225 Highly Flammable liquid and vapor
H302 Harmful if swallowed
H312 Harmful in contact with skin
H314 Causes severe skin burns and eye damage
Precautionary Statements
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment.
Which trade and regulatory codes apply to N,n,n',n'-tetramethylethylenediamine?
HS Code 29212900
UN Number 2372
ADR Class 3
Packing Group II
Storage Class 3 - Flammable liquids
WGK (Germany) 1