Amines
REACH
Tetramethylhexamethylenediamine
CAS Number
111-18-2
EC Number
203-842-9
Abbreviation
TMHDA
What is Tetramethylhexamethylenediamine?
Tetramethylhexamethylenediamine (CAS 111-18-2), abbreviated TMHDA, is a tertiary diamine. Also known as 1,6-Bis(dimethylamino)hexane.
Where is Tetramethylhexamethylenediamine used?
- Polyurethane and epoxy systems: curing and crosslinking agent
- Organometallic and coordination chemistry: catalyst precursor
- Pharmaceutical and fine chemical synthesis: bifunctional amine structure for ligand design
- Personal care: pH regulation with controlled alkalinity and no ionic burden
- Specialty nylon and polyamide development: chain extender or modifier
- It influences gel time and final network density.
Good to know: Pharmaceutical-grade supply is available from select manufacturers where synthesis intermediates require tighter impurity profiles. Buyers should confirm specification documentation on a supplier-by-supplier basis.
Commercial specifications
- Liquid at standard commercial purity levels, typically 98% or higher
Other Names (Synonyms)
1,6-Bis(dimethylamino)hexane|Hexamethylenebis(dimethylamine)|1,6-HEXANEDIAMINE, N,N,N',N'-TETRAMETHYL-|Toyocat MR|Koolizer 1|Minico TMHD|NIAX catalyst C-210|U 1000 (amine)|TMHDA
What are the physical properties of Tetramethylhexamethylenediamine?
Melting Point -46 °C
Boiling Point 104 °C @ Press: 16 Torr
Density 0.7981 g/cm³ @ Temp: 20 °C
Flash Point 165 °F
Appearance clear colorless to yellow liquid
Color Clear colorless to yellow
Form Liquid
Water Solubility miscible
Vapor Pressure 12.4Pa at 20℃
Refractive Index n 20/D 1.4359(lit.)
Log P 1.99 at 23℃
How is Tetramethylhexamethylenediamine classified and handled safely? Learn More
Danger
GHS05· Corrosive GHS06· Toxic GHS07· Irritant GHS08· Health Hazard GHS09· Environmental Hazard
Hazard Statements
H227 Combustible liquid
H301 Toxic if swallowed
H302 Harmful if swallowed
H311 Toxic in contact with skin
Precautionary Statements
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
Which trade and regulatory codes apply to Tetramethylhexamethylenediamine?
HS Code 29212900
UN Number 3390
ADR Class 6.1
Packing Group I
WGK (Germany) 1