Amines REACH

Hexamethylenetetramine

CAS Number
100-97-0
EC Number
202-905-8
E Number
E239

What is Hexamethylenetetramine?

Hexamethylenetetramine (CAS 100-97-0), commonly known as hexamine or HMTA, is a nitrogen-rich cyclic compound used industrially as a curing agent, crosslinker, and biocidal preservative.

Where is Hexamethylenetetramine used?

  • Rubber and tire production: vulcanization accelerator and crosslinking agent for resorcinol-based adhesion systems, improving fiber-to-rubber bonding in belts and tires
  • Phenolic resins: primary curing agent for novolac resins, enabling molding compounds, abrasive wheels, and friction materials
  • Pharmaceuticals: urinary tract antiseptic active ingredient and tablet excipient
  • Leather and textile processing: biocidal preservative and crosslinking agent in tanning and finishing formulations
  • It reacts with phenolic resins and releases formaldehyde in a controlled way.

Commercial specifications

  • Purity: 98% to 99.5% for industrial supply

Other Names (Synonyms)

hexamine|1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane|HMTA|HMT|Urotropin|1,3,5,7-Tetraazaadamantane|Uritone|Aceto HMT

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How is Hexamethylenetetramine classified and handled safely? Learn More

Warning
GHS02· Flammable GHS07· Irritant GHS05· Corrosive GHS08· Health Hazard

Hazard Statements

H228 Flammable solid [Danger Flammable solids]
H317 May cause an allergic skin reaction [Warning Sensitization, Skin]
H361 Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H372 Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
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