Trimethylamine
Description
Trimethylamine (CAS 75-50-3), commonly abbreviated as TMA, is a tertiary amine supplied primarily in anhydrous form for industrial and specialty chemical applications. It functions as a key intermediate and reactant across pharmaceutical synthesis and food-grade flavoring.
Its strong fishy odor profile is both a target compound and a process marker in various manufacturing sectors. FEMA 3241 status confirms its recognized standing as a flavoring substance in regulated food applications.
In food and flavor manufacturing, TMA is used as a reference and active flavoring agent in seafood-type flavor systems. In these environments, its characteristic odor must be precisely controlled or replicated for consistency.
Pharmaceutical producers use it as a building block in the synthesis of choline salts and quaternary ammonium compounds. Both of these appear frequently in finished drug formulations and nutritional supplements.
It also functions as a catalyst and intermediate in the production of ion exchange resins and specialty chemicals. In preservation-related applications, TMA derivatives contribute to biocidal formulations targeting microbial control.
Trimethylamine is supplied as a compressed anhydrous gas or as aqueous solution, typically at concentrations of 30 to 45 percent in water. Food-grade and technical-grade designations are the most commonly available specifications.
Packaging ranges from pressurized cylinders for anhydrous supply to drum quantities for aqueous grades. This ensures safe handling and transport according to the specific requirements of the industrial or laboratory facility.
Physical Properties
| Melting Point | -117.1 °C |
| Boiling Point | 2.8 °C |
| Density | 0.627 g/cm³ @ Temp: 25 °C |
| Flash Point | 38 °F |
| Appearance | Trimethylamine is compressed gas or liquid. Flammable gas. Shipped as a compressed gas, it may be present in an aqueous solution. It has a strong, fishy, ammoniacal odor. The Odor Threshold is 0.00011-0.87 ppm. Warning: The Odor Threshold range is so broad that odor alone should not be used as a warning of potentially hazardous exposures. |
| Color | Colorless |
| Odor | smelling like rotting fish, rotting eggs, garbage, or urine. |
| Form | Liquid |
| Water Solubility | Soluble In Water, 8.9e+005 mg/L. |
| Vapor Pressure | 430 mm Hg ( 25 °C) |
| Refractive Index | n 20/D 1.357 |
| pH | a strong base (pH 9.8) |
| Log P | 0.06 |
Safety & Handling (Learn More)
Trade & Regulatory
| HS Code | 29211100 |
| UN Number | 2924 |
| ADR Class | 3 |
| Packing Group | II |
| Storage Class | 2A - Gases |
| WGK (Germany) | 1 |
Documentation
Other Names
trimethylamine anhydrous|NMe3|N(CH3)3|N,N,N-trimethylamine|N,N-dimethyl-methanamine|N-trimethylamine|TMA|Methanamine, N,N-dimethyl-
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