Amines REACH

Trimethylamine

CAS Number
75-50-3
EC Number
200-875-0
Chemical Formula
C3H9N
Molecular Weight
59.11 g/mol
FEMA Number
FEMA 3241
Abbreviation
TMA

Description

Trimethylamine (CAS 75-50-3), commonly abbreviated as TMA, is a tertiary amine supplied primarily in anhydrous form for industrial and specialty chemical applications. It functions as a key intermediate and reactant across pharmaceutical synthesis and food-grade flavoring. Its strong fishy odor profile is both a target compound and a process marker in various manufacturing sectors. FEMA 3241 status confirms its recognized standing as a flavoring substance in regulated food applications.

In food and flavor manufacturing, TMA is used as a reference and active flavoring agent in seafood-type flavor systems. In these environments, its characteristic odor must be precisely controlled or replicated for consistency. Pharmaceutical producers use it as a building block in the synthesis of choline salts and quaternary ammonium compounds. Both of these appear frequently in finished drug formulations and nutritional supplements.

It also functions as a catalyst and intermediate in the production of ion exchange resins and specialty chemicals. In preservation-related applications, TMA derivatives contribute to biocidal formulations targeting microbial control. Trimethylamine is supplied as a compressed anhydrous gas or as aqueous solution, typically at concentrations of 30 to 45 percent in water. Food-grade and technical-grade designations are the most commonly available specifications.

Packaging ranges from pressurized cylinders for anhydrous supply to drum quantities for aqueous grades. This ensures safe handling and transport according to the specific requirements of the industrial or laboratory facility.

Other Names (Synonyms)

trimethylamine anhydrous|NMe3|N(CH3)3|N,N,N-trimethylamine|N,N-dimethyl-methanamine|N-trimethylamine|TMA|Methanamine, N,N-dimethyl-

Key Technical Features

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Physical Properties

Melting Point -117.1 °C
Boiling Point 2.8 °C
Density 0.627 g/cm³ @ Temp: 25 °C
Flash Point 38 °F
Appearance Trimethylamine is compressed gas or liquid. Flammable gas. Shipped as a compressed gas, it may be present in an aqueous solution. It has a strong, fishy, ammoniacal odor. The Odor Threshold is 0.00011-0.87 ppm. Warning: The Odor Threshold range is so broad that odor alone should not be used as a warning of potentially hazardous exposures.
Color Colorless
Odor smelling like rotting fish, rotting eggs, garbage, or urine.
Form Liquid
Water Solubility Soluble In Water, 8.9e+005 mg/L.
Vapor Pressure 430 mm Hg ( 25 °C)
Refractive Index n 20/D 1.357
pH a strong base (pH 9.8)
Log P 0.06

Documentation

Safety & Handling Learn More

Danger
GHS02· Flammable GHS04· Compressed Gas GHS05· Corrosive GHS07· Irritant GHS08· Health Hazard

Hazard Statements

H220 Extremely flammable gas
H224 Extremely flammable liquid and vapor
H280 Contains gas under pressure; may explode if heated
H302 Harmful if swallowed

Precautionary Statements

P203 Obtain, consult and follow expert instructions for use.
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P222 Do not allow contact with air.
P233 Keep container tightly closed.

Trade & Regulatory

HS Code 29211100
UN Number 2924
ADR Class 3
Packing Group II
Storage Class 2A - Gases
WGK (Germany) 1
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