Methanesulfonyl chloride
CAS Number
124-63-0
EC Number
204-706-1
Industries: Pharma & Healthcare
What is Methanesulfonyl chloride?
Methanesulfonyl chloride (CAS 124-63-0), commonly known as mesyl chloride, is a highly reactive sulfonylating agent used in pharmaceutical and agrochemical synthesis.
Where is Methanesulfonyl chloride used?
- Pharmaceutical manufacturing: preparation of mesylate intermediates for APIs requiring controlled stereochemistry
- Agrochemicals: sulfonylation steps in herbicides, fungicides and insecticides
- Drug discovery: preparation of sulfonamide compounds
- Contract research organizations: protecting group chemistry
- It converts hydroxyl groups into mesylate leaving groups for substitution, elimination and cyclization.
Good to know: Buyers should confirm purity specifications and moisture-control packaging when sourcing for GMP-aligned production environments.
Commercial specifications
- Technical and high-purity grades
- Packaging from small laboratory quantities to bulk drums
Other Names (Synonyms)
Mesyl chloride|Methanesulphonyl chloride|Methyl sulfochloride|METHYLSULFONYL CHLORIDE|Chloro methyl sulfone|Methanesulfonic acid chloride|Methanesulfuryl chloride
How is Methanesulfonyl chloride classified and handled safely? Learn More
Danger
GHS05· Corrosive GHS06· Toxic GHS07· Irritant GHS08· Health Hazard
Hazard Statements
H301 Toxic if swallowed [Danger Acute toxicity, oral]
H311 Toxic in contact with skin [Danger Acute toxicity, dermal]
H314 Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H318 Causes serious eye damage [Danger Serious eye damage/eye irritation]
H330 Fatal if inhaled [Danger Acute toxicity, inhalation]
H370 Causes damage to organs [Danger Specific target organ toxicity, single exposure]