Bromotrimethylsilane

Bromotrimethylsilane (CAS 2857-97-8), commonly abbreviated as TMSBr, is a reactive organosilicon reagent used in pharmaceutical synthesis and specialty chemical manufacturing.

Where is Bromotrimethylsilane used?

• Pharmaceutical API synthesis: converts phosphonate esters to phosphonic acids for antiviral and nucleotide analog drugs
• Polymer chemistry: introduces trimethylsilyl groups onto polymer backbones, modifying surface adhesion and compatibility for specialty coatings and adhesives
• Fine chemical and agrochemical synthesis: activates esters and ethers under mild conditions
• Cosmetic and personal care: controlled surface modification in silicone-based systems
• It functions as a silylating agent and Lewis acid activator.

Good to know: Anhydrous grades are standard given the compound's sensitivity to moisture.

Commercial specifications

• Purity typically 97% or greater
• Packaging from small reagent quantities to multi-kilogram drums