Isopropyl chloroformate
CAS Number
108-23-6
EC Number
203-563-2
Industries: Pharma & Healthcare
What is Isopropyl chloroformate?
Isopropyl chloroformate (CAS 108-23-6), also known as isopropyl chlorocarbonate, is a reactive acylating agent used in organic synthesis to introduce the isopropoxycarbonyl protecting group onto amines, alcohols, and other nucleophiles.
Where is Isopropyl chloroformate used?
- Pharmaceutical synthesis: activates carboxylic acids as mixed anhydrides for peptide bond formation in peptide-based APIs and small-molecule drugs
- Agrochemicals: introduces carbamate linkages in crop protection compounds
- Fine chemical and biotechnology research: preparation of isopropyl carbonate esters
- Contract synthesis labs and API producers rely on it for protecting group strategies in multi-step synthesis.
Good to know: Stabilized form controls reactivity during storage and transport.
Commercial specifications
- Purity 97% to 99%+ for pharmaceutical intermediate applications
- Small quantities for laboratory use; bulk drums for industrial-scale synthesis
Other Names (Synonyms)
ISOPROPYL CHLOROCARBONATE|Chloroformic acid isopropyl ester|Carbonochloridic acid, 1-methylethyl ester|Isopropyl chloromethanoate|Formic acid, chloro-, isopropyl ester|1-methylethyl chloroformate|2-propyl chloroformate
What are the physical properties of Isopropyl chloroformate?
Boiling Point 104.6 °C @ Press: 761 Torr
Density 1.08 g/cm³
Flash Point 43 °F
Appearance Clear colorless solution
Form liquid
Vapor Pressure 27.998hPa at 20℃
Refractive Index n 20/D 1.485(lit.)
How is Isopropyl chloroformate classified and handled safely? Learn More
Danger
GHS02· Flammable GHS05· Corrosive GHS06· Toxic GHS07· Irritant GHS08· Health Hazard
Hazard Statements
H225 Highly Flammable liquid and vapor
H302 Harmful if swallowed
H314 Causes severe skin burns and eye damage
H315 Causes skin irritation
Precautionary Statements
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment.
Which trade and regulatory codes apply to Isopropyl chloroformate?
HS Code 29159000
UN Number 3286
ADR Class 3
Packing Group II
Storage Class 3 - Flammable liquids
WGK (Germany) 2