4-bromophenyl isocyanate
Description
4-Bromophenyl isocyanate (CAS 2493-02-9), also known as p-bromophenyl isocyanate, is a reactive aryl isocyanate used as a building block in organic synthesis and polymer chemistry.
The bromine substituent provides a handle for further functionalization, making it a practical intermediate for constructing complex molecular architectures in pharmaceutical and specialty chemical workflows.
In pharmaceutical synthesis, it serves as a key intermediate for preparing urea-containing drug candidates and bioactive compounds where the bromine atom enables downstream cross-coupling reactions.
Agrochemical and fine chemical manufacturers use it to introduce the bromophenyl-urea motif into active ingredient scaffolds. In polymer research, it functions as a monomer for producing specialty polyureas.
Biotechnology researchers also employ it in the preparation of labeled probes and derivatization reagents for analytical applications. It is supplied as a liquid or low-melting solid in high-purity grades.
Standard offerings include reagent-grade and synthesis-grade material, with purity specifications commonly at 97% or higher by GC. Packaging ranges from small quantities to bulk quantities for industrial use.
Physical Properties
| Melting Point | 134 °C |
| Boiling Point | 78-80 °C @ Press: 5 Torr |
| Density | 1.6077 (rough estimate) |
| Flash Point | 229 °F |
| Appearance | WHITE TO LIGHT BEIGE CRYSTALLINE SOLID |
| Color | White to light beige |
| Form | Crystalline Solid |
| Water Solubility | Sparingly soluble in water (0.40 g/L at 25°C). |
| Refractive Index | 1.5500 (estimate) |
Safety & Handling (Learn More)
Trade & Regulatory
| HS Code | 29291090 |
| WGK (Germany) | 3 |
Documentation
Other Names
p-Bromophenyl isocyanate|4-bromophenylcarbimide|Isocyanic acid, p-bromophenyl ester|MGR77M31ZW|P-BROMOPHENYLCARBONIMIDE|Benzene, 1-bromo-4-isocyanato-|1-Bromo-4-isocyanatobenzene
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