4-bromophenyl isocyanate

CAS Number
2493-02-9
EC Number
219-662-9

What is 4-bromophenyl isocyanate?

4-Bromophenyl isocyanate (CAS 2493-02-9), also known as p-bromophenyl isocyanate, is a reactive aryl isocyanate used as a building block in organic synthesis and polymer chemistry.

Where is 4-bromophenyl isocyanate used?

  • Pharmaceutical synthesis: intermediate for urea-containing drug candidates and bioactive compounds, with bromine enabling cross-coupling
  • Agrochemical and fine chemical manufacturing: introduces the bromophenyl-urea motif into active ingredient scaffolds
  • Polymer research: monomer for specialty polyureas
  • Biotechnology: preparation of labeled probes and derivatization reagents for analytical applications
  • The bromine substituent provides a handle for further functionalization in pharmaceutical and specialty chemical workflows.

Commercial specifications

  • Purity commonly 97% or higher by GC
  • Packaging from small to bulk quantities

Other Names (Synonyms)

p-Bromophenyl isocyanate|4-bromophenylcarbimide|Isocyanic acid, p-bromophenyl ester|MGR77M31ZW|P-BROMOPHENYLCARBONIMIDE|Benzene, 1-bromo-4-isocyanato-|1-Bromo-4-isocyanatobenzene

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What are the physical properties of 4-bromophenyl isocyanate?

Melting Point 134 °C
Boiling Point 78-80 °C @ Press: 5 Torr
Density 1.6077 (rough estimate)
Flash Point 229 °F
Appearance WHITE TO LIGHT BEIGE CRYSTALLINE SOLID
Color White to light beige
Form Crystalline Solid
Water Solubility Sparingly soluble in water (0.40 g/L at 25°C).
Refractive Index 1.5500 (estimate)

How is 4-bromophenyl isocyanate classified and handled safely? Learn More

Danger
GHS07· Irritant GHS08· Health Hazard

Hazard Statements

H312 Harmful in contact with skin
H315 Causes skin irritation
H319 Causes serious eye irritation
H332 Harmful if inhaled
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335 May cause respiratory irritation

Precautionary Statements

P233 Keep container tightly closed.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.

Which trade and regulatory codes apply to 4-bromophenyl isocyanate?

HS Code 29291090
WGK (Germany) 3
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