4-carboxyphenylboronic acid

4-Carboxyphenylboronic acid (CAS 14047-29-1), also known as 4-boronobenzoic acid, is a bifunctional arylboronic acid combining a carboxylic acid and a boronic acid group on a single benzene ring.

Where is 4-carboxyphenylboronic acid used?

• Pharmaceutical synthesis: key intermediate in Suzuki–Miyaura cross-coupling reactions
• Drug discovery: construction of biaryl scaffolds found in active pharmaceutical ingredients
• Polymer chemistry: introduces boronic acid functionality into hydrogels and responsive materials
• Glucose sensing and controlled release: reversible covalent bonding with diols
• Personal care: boronic acid moiety supports antimicrobial and preservative activity by interacting with bacterial cell wall components
• Surface functionalization and bioconjugate chemistry: carboxylic acid group allows direct conjugation to amine-bearing substrates.

Commercial specifications

• Purity grades typically range from 97% to 99%+ for synthesis-grade and high-purity pharmaceutical applications
• Specification against HPLC purity standards is standard for pharma-facing supply chains
• Research quantities through to multi-kilogram commercial lots