4-aminobenzoic acid

CAS Number
150-13-0
EC Number
205-753-0
Abbreviation
PABA

What is 4-aminobenzoic acid?

4-Aminobenzoic acid (CAS 150-13-0), commonly known as PABA or para-aminobenzoic acid, is an aromatic amino acid derivative used as a key building block in pharmaceutical synthesis.

Where is 4-aminobenzoic acid used?

  • Pharmaceuticals: precursor in the synthesis of local anesthetics such as benzocaine and procaine, as well as folate-class compounds
  • Textile and leather: intermediate in azo dye production for colorfast, high-affinity dye systems
  • Personal care: UV-B absorbing agents in sunscreen formulations
  • Specialty polymers and coatings: crosslinking and surface-modifying agent
  • Its bifunctional structure, carrying both an amine and a carboxylic acid group, makes it a reactive intermediate for producing dyes, UV absorbers, and active pharmaceutical ingredients.

Good to know: Demand has shifted toward its ester forms in recent years.

Commercial specifications

  • Bulk quantities for industrial synthesis; smaller quantities for R&D use

Other Names (Synonyms)

para-aminobenzoic acid|p-carboxyphenylamine|p-carboxyaniline|p-aminobenzoic acid|gamma-aminobenzoic acid|aniline-4-carboxylic acid|4-carboxyphenylamine|4-carboxyaniline|PABA

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What are the physical properties of 4-aminobenzoic acid?

Melting Point 188.5 °C
Boiling Point 200 °C @ Press: 10 Torr
Density 1.367-1.395 g/cm³
Flash Point 250 °C
Appearance White to off white crystalline powder
Color White to light yellow
Odor Odorless
Form Crystalline Powder
Water Solubility 4.7 g/L (20 ºC)
Vapor Pressure 0Pa at 25℃
Refractive Index 1.5323 (estimate)
pH 3.5 (5g/l, H2O, 20℃)
Log P 0.96 at 25℃

How is 4-aminobenzoic acid classified and handled safely? Learn More

Warning
GHS07· Irritant

Hazard Statements

H315 Causes skin irritation
H317 May cause an allergic skin reaction
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H412 Harmful to aquatic life with long lasting effects

Precautionary Statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P272 Contaminated work clothing should not be allowed out of the workplace.

Which trade and regulatory codes apply to 4-aminobenzoic acid?

HS Code 29224995
Storage Class 11 - Combustible Solids
WGK (Germany) 3
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