SoleChem

4-aminobenzoic acid

Pharmaceutical Intermediates Pharmaceuticals & Healthcare
CAS
150-13-0
EC
205-753-0
Mol. Weight
137.14 g/mol

Description

4-Aminobenzoic acid (CAS 150-13-0), commonly known as PABA or para-aminobenzoic acid, is an aromatic amino acid derivative used as a key building block in pharmaceutical synthesis.

Its bifunctional structure, carrying both an amine and a carboxylic acid group, makes it a reactive intermediate for producing dyes, UV absorbers, and active pharmaceutical ingredients.

In pharmaceuticals, PABA serves as a precursor in the synthesis of local anesthetics such as benzocaine and procaine, as well as folate-class compounds for various medical uses.

Textile and leather processors use it as an intermediate in azo dye production, where it contributes to colorfast, high-affinity dye systems for natural and synthetic fibers.

In sunscreen and personal care formulations, PABA derivatives function as UV-B absorbing agents, though demand has shifted toward its ester forms in recent years.

It also acts as a crosslinking and surface-modifying agent in specialty polymer and coating applications, providing versatility across multiple industrial chemical sectors.

4-Aminobenzoic acid is supplied as a white to off-white crystalline powder. Standard commercial grades include technical and pharmaceutical-grade material for diverse needs.

The pharmaceutical supply conforms to USP and BP specifications. Bulk quantities are available for industrial synthesis, with smaller quantities offered for R&D use.

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Physical Properties

Melting Point 188.5 °C
Boiling Point 200 °C @ Press: 10 Torr
Density 1.367-1.395 g/cm³
Flash Point 250 °C
Appearance White to off white crystalline powder
Color White to light yellow
Odor Odorless
Form Crystalline Powder
Water Solubility 4.7 g/L (20 ºC)
Vapor Pressure 0Pa at 25℃
Refractive Index 1.5323 (estimate)
pH 3.5 (5g/l, H2O, 20℃)
Log P 0.96 at 25℃

Safety & Handling (Learn More)

Warning GHS07
Hazard Statements
H315 Causes skin irritation
H317 May cause an allergic skin reaction
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H412 Harmful to aquatic life with long lasting effects
Precautionary Statements
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P319 Get medical advice/attention if you feel unwell.
P321 Specific treatment (see … on this label).
P405 Store locked up.
P501 Dispose of contents/container in accordance with local regulations.
P264+P265 Wash … thoroughly after handling.
P302+P352 IF ON SKIN: Wash with plenty of water.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P332+P317 Get emergency medical help.
P333+P317 Get emergency medical help.
P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code 29224995
Storage Class 11 - Combustible Solids
WGK (Germany) 3

Documentation

Other Names

para-aminobenzoic acid|p-carboxyphenylamine|p-carboxyaniline|p-aminobenzoic acid|gamma-aminobenzoic acid|aniline-4-carboxylic acid|4-carboxyphenylamine|4-carboxyaniline|PABA

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