Amines
REACH
4-aminophenol
CAS Number
123-30-8
EC Number
204-616-2
What is 4-aminophenol?
4-Aminophenol (CAS 123-30-8), also known as p-aminophenol, is a primary aromatic amine; a key chemical intermediate in pharmaceutical synthesis and specialty chemical manufacturing.
Where is 4-aminophenol used?
- Pharmaceuticals: direct precursor to paracetamol
- Hair dye formulations: oxidative colorant intermediate that couples with other components to produce permanent color
- Photographic developer intermediate in printing and imaging chemistry
- Rubber and polymer processing: antioxidant precursor in the synthesis of stabilizer compounds
- Its reactivity toward acylation and coupling reactions makes it a building block across multiple industrial sectors.
Good to know: Technical grade is the standard commercial form; pharmaceutical-grade material meets API intermediate specifications including purity requirements aligned with USP, Ph. Eur. standards.
Commercial specifications
- Packaging ranges from small drums to bulk quantities
Other Names (Synonyms)
p-hydroxyphenylamine|p-hydroxyaniline|4-hydroxyaniline|4-aminobenzenol|4-amino-1-hydroxybenzene|1-amino-4-hydroxybenzene|p-aminophenol|Phenol, 4-amino-
What are the physical properties of 4-aminophenol?
Melting Point 189.6-190.2 °C
Boiling Point 284 °C
Density 1.29
Flash Point 189 °C
Appearance o-Aminophenol appears as colorless needles or as white crystalline substance turning tan to brown on exposure to air.
Color White to cream
Form Crystalline Powder
Water Solubility 1.5 g/100 mL (20 ºC)
Vapor Pressure 0.4 hPa (110 °C)
Refractive Index 1.5444 (estimate)
Log P -0.09-0.04 at 25℃
How is 4-aminophenol classified and handled safely? Learn More
Warning
GHS07· Irritant GHS08· Health Hazard GHS09· Environmental Hazard
Hazard Statements
H302 Harmful if swallowed [Warning Acute toxicity, oral]
H332 Harmful if inhaled [Warning Acute toxicity, inhalation]
H341 Suspected of causing genetic defects [Warning Germ cell mutagenicity]
H400 Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
Which trade and regulatory codes apply to 4-aminophenol?
HS Code 28402090
UN Number 2512
ADR Class 6.1
Packing Group III
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
WGK (Germany) 3