Phenacetin

CAS Number
62-44-2
EC Number
200-533-0

What is Phenacetin?

Phenacetin (CAS 62-44-2), also known as p-Acetophenetidide, is a synthetic acetamide compound used as a pharmaceutical intermediate and chemical building block.

Where is Phenacetin used?

  • Pharmaceutical and fine chemical: intermediate for synthesizing active compounds and research-grade formulations
  • Polymer and specialty chemical manufacturing: antioxidant stabilizer and processing aid
  • Plastics and polymer processing: stabilizer that inhibits oxidative degradation during high-temperature compounding
  • Textile and leather processing: surface modifier and auxiliary agent that improves dye uptake and substrate compatibility
  • Personal care formulators have historically incorporated it into preservation and stabilization systems.

Good to know: Standard grades include USP and BP, with pharmaceutical-grade material subject to tighter purity thresholds typically above 99%.

Commercial specifications

  • Pharmaceutical-grade purity thresholds typically above 99%
  • Bulk quantities in multi-kilogram and metric-ton packaging
  • Smaller quantities for laboratory and formulation development use

Other Names (Synonyms)

N-(4-ethoxyphenyl)acetamide|p-Acetophenetidide|Acetamide, N-(4-ethoxyphenyl)-|PENACETIN

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What are the physical properties of Phenacetin?

Melting Point 134-135 °C
Boiling Point 132 °C / 4mmHg
Density 1.2404 g/cm³
Flash Point 2°C
Appearance white crystalline powder
Color White
Form powder
Water Solubility 0.076 g/100 mL
Refractive Index 1.5710
Log P 1.580

How is Phenacetin classified and handled safely? Learn More

Danger
GHS07· Irritant GHS08· Health Hazard

Hazard Statements

H302 Harmful if swallowed
H341 Suspected of causing genetic defects
H350 May cause cancer
H362 May cause harm to breast-fed children
H370 Causes damage to organs
H372 Causes damage to organs through prolonged or repeated exposure

Precautionary Statements

P203 Obtain, consult and follow expert instructions for use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy and while nursing.
P264 Wash … thoroughly after handling.

Which trade and regulatory codes apply to Phenacetin?

HS Code 29251995
UN Number 3077
ADR Class 9
Packing Group III
Storage Class 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
WGK (Germany) 3
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