Paracetamol

CAS Number
103-90-2
EC Number
203-157-5
Abbreviation
APAP

What is Paracetamol?

Paracetamol (CAS 103-90-2), also known as APAP (acetaminophen), is a globally sourced active pharmaceutical ingredient used as an analgesic and antipyretic in finished dosage forms.

Where is Paracetamol used?

  • Pharmaceutical manufacturing: primary API in tablets, capsules, syrups and effervescent formulations
  • Pediatric liquids: high-demand segment needing specific particle size and solubility profiles
  • Combination products: compounded with antihistamines, decongestants and caffeine for cold and flu preparations
  • Personal care: evaluated as a UV stabilizer in formulation research
  • It targets pain relief and fever reduction across various demographics.

Good to know: Ph. Eur. and USP grades are most commonly required by regulated-market buyers for quality assurance. GMP-certified manufacturing documentation is typically required for pharmaceutical procurement.

Commercial specifications

  • White crystalline powder in standard and fine particle grades
  • Recognized specifications include BP, USP, Ph. Eur. and IP (Indian Pharmacopoeia)
  • Bulk supply in fiber drums or multiwall bags

Other Names (Synonyms)

p-hydroxyphenolacetamide|p-hydroxyacetanilide|p-hydroxy-acetanilid|p-acetylaminophenol|p-acetaminophenol|p-acetamidophenol|N-acetyl-p-aminophenol4-hydroxyacetanilide|N-(4-hydroxyphenyl)acetamide|APAP

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What are the physical properties of Paracetamol?

Melting Point 169-170.5 °C
Boiling Point 500 °C
Density 1.293 g/cm³ @ Temp: 21 °C
Flash Point 11 °C
Appearance White Solid
Color White
Odor odorless
Form Crystals or Crystalline Powder
Water Solubility 14 g/L (20 ºC)
Vapor Pressure 0.008Pa at 25℃
Refractive Index 1.5810 (rough estimate)
pH 5.5-6.5 (H2O, 20℃)(saturated solution)
Log P 1.098 at 25℃

How is Paracetamol classified and handled safely? Learn More

Warning
GHS07· Irritant GHS09· Environmental Hazard GHS08· Health Hazard

Hazard Statements

H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation

Precautionary Statements

P203 Obtain, consult and follow expert instructions for use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.

Which trade and regulatory codes apply to Paracetamol?

HS Code 29242930
UN Number 3077
ADR Class 9
Packing Group III
WGK (Germany) 1
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