Paracetamol
Description
Paracetamol (CAS 103-90-2), also known as APAP (acetaminophen), is a globally sourced active pharmaceutical ingredient used as an analgesic and antipyretic in finished dosage forms. It is one of the highest-volume OTC drug substances in the world.
With established supply chains across regulated and emerging markets, it serves as a cornerstone of modern medicine. In pharmaceutical manufacturing, it is the primary API in tablets, capsules, syrups, and effervescent formulations.
These products target pain relief and fever reduction across various demographics. Pediatric liquid formulations represent a distinct high-demand segment, requiring specific particle size and solubility profiles that influence grade selection.
It is also compounded into combination products alongside antihistamines, decongestants, and caffeine for cold and flu preparations. In personal care, it is evaluated as a UV stabilizer in select formulation research.
Despite niche uses, pharmaceutical applications dominate procurement volume globally. The material is supplied as a white crystalline powder in standard and fine particle grades to meet diverse manufacturing needs.
Recognized specifications include BP, USP, Ph.Eur., and IP (Indian Pharmacopoeia). The Ph.Eur. and USP grades are most commonly required by regulated-market buyers for quality assurance.
Bulk supply is available in fiber drums or multiwall bags for industrial use. GMP-certified manufacturing documentation is typically required for pharmaceutical procurement to ensure compliance with international safety standards.
Physical Properties
| Melting Point | 169-170.5 °C |
| Boiling Point | 500 °C |
| Density | 1.293 g/cm³ @ Temp: 21 °C |
| Flash Point | 11 °C |
| Appearance | White Solid |
| Color | White |
| Odor | odorless |
| Form | Crystals or Crystalline Powder |
| Water Solubility | 14 g/L (20 ºC) |
| Vapor Pressure | 0.008Pa at 25℃ |
| Refractive Index | 1.5810 (rough estimate) |
| pH | 5.5-6.5 (H2O, 20℃)(saturated solution) |
| Log P | 1.098 at 25℃ |
Safety & Handling (Learn More)
Trade & Regulatory
| HS Code | 29242930 |
| UN Number | 3077 |
| ADR Class | 9 |
| Packing Group | III |
| WGK (Germany) | 1 |
Documentation
Other Names
p-hydroxyphenolacetamide|p-hydroxyacetanilide|p-hydroxy-acetanilid|p-acetylaminophenol|p-acetaminophenol|p-acetamidophenol|N-acetyl-p-aminophenol4-hydroxyacetanilide|N-(4-hydroxyphenyl)acetamide|APAP
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