Paracetamol

CAS Number
103-90-2
EC Number
203-157-5
Chemical Formula
C8H9NO2
Molecular Weight
151.16 g/mol
Abbreviation
APAP

Description

Paracetamol (CAS 103-90-2), also known as APAP (acetaminophen), is a globally sourced active pharmaceutical ingredient used as an analgesic and antipyretic in finished dosage forms. It is one of the highest-volume OTC drug substances in the world. With established supply chains across regulated and emerging markets, it serves as a cornerstone of modern medicine. In pharmaceutical manufacturing, it is the primary API in tablets, capsules, syrups, and effervescent formulations.

These products target pain relief and fever reduction across various demographics. Pediatric liquid formulations represent a distinct high-demand segment, requiring specific particle size and solubility profiles that influence grade selection. It is also compounded into combination products alongside antihistamines, decongestants, and caffeine for cold and flu preparations. In personal care, it is evaluated as a UV stabilizer in select formulation research.

Despite niche uses, pharmaceutical applications dominate procurement volume globally. The material is supplied as a white crystalline powder in standard and fine particle grades to meet diverse manufacturing needs. Recognized specifications include BP, USP, Ph.Eur., and IP (Indian Pharmacopoeia). The Ph.Eur. and USP grades are most commonly required by regulated-market buyers for quality assurance.

Bulk supply is available in fiber drums or multiwall bags for industrial use. GMP-certified manufacturing documentation is typically required for pharmaceutical procurement to ensure compliance with international safety standards.

Other Names (Synonyms)

p-hydroxyphenolacetamide|p-hydroxyacetanilide|p-hydroxy-acetanilid|p-acetylaminophenol|p-acetaminophenol|p-acetamidophenol|N-acetyl-p-aminophenol4-hydroxyacetanilide|N-(4-hydroxyphenyl)acetamide|APAP

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

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Physical Properties

Melting Point 169-170.5 °C
Boiling Point 500 °C
Density 1.293 g/cm³ @ Temp: 21 °C
Flash Point 11 °C
Appearance White Solid
Color White
Odor odorless
Form Crystals or Crystalline Powder
Water Solubility 14 g/L (20 ºC)
Vapor Pressure 0.008Pa at 25℃
Refractive Index 1.5810 (rough estimate)
pH 5.5-6.5 (H2O, 20℃)(saturated solution)
Log P 1.098 at 25℃

Documentation

Safety & Handling Learn More

Warning
GHS07· Irritant GHS09· Environmental Hazard GHS08· Health Hazard

Hazard Statements

H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation

Precautionary Statements

P203 Obtain, consult and follow expert instructions for use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.

Trade & Regulatory

HS Code 29242930
UN Number 3077
ADR Class 9
Packing Group III
WGK (Germany) 1
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