SoleChem

5-aminosalicylic acid

Organic Acids Personal Care & Cosmetics
CAS
89-57-6
EC
201-919-1
Mol. Weight
153.14 g/mol

Description

5-Aminosalicylic acid (CAS 89-57-6) is an aminosalicylate compound used as an active pharmaceutical ingredient and synthesis intermediate across pharmaceutical and personal care manufacturing.

In finished drug products, it functions as the primary therapeutic agent in inflammatory bowel disease formulations. In cosmetic applications, it is evaluated for UV-stabilizing and preservation activity.

The primary commercial demand for 5-ASA is as the active ingredient in mesalazine-branded oral and rectal pharmaceutical formulations, including delayed-release tablets, suppositories, and enemas.

Contract manufacturers and formulators also source it as a key intermediate in the synthesis of azo-linked prodrugs such as sulfasalazine and olsalazine for various medical applications.

In personal care, it is incorporated into formulations targeting UV protection and antimicrobial preservation, particularly where multifunctional actives are preferred by chemical buyers.

Specialty chemical buyers additionally source 5-ASA as a building block for dye intermediates and fine chemical synthesis. It is supplied as a fine off-white to pale yellow powder.

Pharmaceutical-grade material is available to USP, BP, and Ph. Eur. specifications, which are the standard requirements for API procurement in the industry.

Technical-grade material is also available for industrial synthesis applications. These standards ensure the highest level of purity and consistency for global manufacturing partners.

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Physical Properties

Melting Point 283 °C
Boiling Point 276.03°C (rough estimate)
Density 1.5 g/cm³
Flash Point 279-281°C
Appearance Off-White Crystals
Color off-white to gray
Form tablets
Water Solubility <0.1 g/100 mL at 21 ºC
Vapor Pressure 0Pa at 25℃
Refractive Index 1.5500 (estimate)
pH 4.0-4.1 (0.8g/l, H2O, 20℃)
Log P 0.98 at 25℃

Safety & Handling (Learn More)

Warning GHS07
Hazard Statements
H315 Causes skin irritation
H317 May cause an allergic skin reaction
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H412 Harmful to aquatic life with long lasting effects
Precautionary Statements
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P319 Get medical advice/attention if you feel unwell.
P321 Specific treatment (see … on this label).
P405 Store locked up.
P501 Dispose of contents/container in accordance with local regulations.
P264+P265 Wash … thoroughly after handling.
P302+P352 IF ON SKIN: Wash with plenty of water.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P332+P317 Get emergency medical help.
P333+P317 Get emergency medical help.
P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code 29225000
WGK (Germany) 2

Documentation

Other Names

Pentasa®|p-Aminosalicylsaeure|Mésalazine|m-Aminosalicylic acid|3-carboxy-4-hydroxyaniline|5-ASA|5-Aminosalicylate|5-Amino-2-hydroxybenzoic acid

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