5-aminosalicylic acid
CAS Number
89-57-6
EC Number
201-919-1
Abbreviation
5-ASA
What is 5-aminosalicylic acid?
5-Aminosalicylic acid (CAS 89-57-6) is an aminosalicylate compound used as an active pharmaceutical ingredient and synthesis intermediate.
Where is 5-aminosalicylic acid used?
- Pharmaceuticals: primary therapeutic agent in inflammatory bowel disease formulations
- Pharmaceuticals: active ingredient in mesalazine-branded oral and rectal formulations, including delayed-release tablets, suppositories, and enemas
- Pharmaceuticals: intermediate in the synthesis of azo-linked prodrugs such as sulfasalazine and olsalazine
- Personal care: UV-stabilizing and preservation activity
- Specialty chemicals: building block for dye intermediates and fine chemical synthesis
Other Names (Synonyms)
Pentasa®|p-Aminosalicylsaeure|Mésalazine|m-Aminosalicylic acid|3-carboxy-4-hydroxyaniline|5-ASA|5-Aminosalicylate|5-Amino-2-hydroxybenzoic acid
What are the physical properties of 5-aminosalicylic acid?
Melting Point 283 °C
Boiling Point 276.03°C (rough estimate)
Density 1.5 g/cm³
Flash Point 279-281°C
Appearance Off-White Crystals
Color off-white to gray
Form tablets
Water Solubility <0.1 g/100 mL at 21 ºC
Vapor Pressure 0Pa at 25℃
Refractive Index 1.5500 (estimate)
pH 4.0-4.1 (0.8g/l, H2O, 20℃)
Log P 0.98 at 25℃
How is 5-aminosalicylic acid classified and handled safely? Learn More
Warning
GHS07· Irritant
Hazard Statements
H315 Causes skin irritation
H317 May cause an allergic skin reaction
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H412 Harmful to aquatic life with long lasting effects
Precautionary Statements
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P272 Contaminated work clothing should not be allowed out of the workplace.
Which trade and regulatory codes apply to 5-aminosalicylic acid?
HS Code 29225000
WGK (Germany) 2