Azelaic acid

CAS Number
123-99-9
EC Number
204-669-1

What is Azelaic acid?

Azelaic acid (CAS 123-99-9) is a saturated dicarboxylic acid used as a functional building block and active ingredient. Also marketed under the pharmaceutical trade names Skinoren and Skinorem.

Where is Azelaic acid used?

  • Personal care and pharmaceuticals: active ingredient in topical products targeting acne and hyperpigmentation, functioning as a pH-regulating and antimicrobial agent
  • Polymers: monomer for polyamides and polyesters with improved flexibility and low-temperature performance, particularly in specialty coatings and adhesives
  • Lubricants: esters from esterification with branched alcohols serve as synthetic base fluids and plasticizers for high-performance and low-temperature applications
  • It also acts as a corrosion inhibitor and dispersant additive in metalworking fluids.

Good to know: Standard commercial grades include technical, cosmetic, and pharmaceutical grades, with the latter meeting USP and Ph. Eur. specifications.

Commercial specifications

  • Purity levels of 98–99%+ are typical for high-specification applications

Other Names (Synonyms)

Skinoren|Skinorem|Polyazelaic anhydride|Nonanedioic acid homopolymer|Nonanedioic acid azelaic acid|Nonanedioic acid|Nonandisäure

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What are the physical properties of Azelaic acid?

Melting Point 106.5 °C
Boiling Point 225 °C @ Press: 10 Torr
Density 1.251 g/cm³
Flash Point 215 °C
Appearance white to cream solid
Color White to slightly yellow
Form Slightly Crystalline Powder or Flakes
Water Solubility 2.4 g/L (20 ºC)
Vapor Pressure <1 mm Hg ( 20 °C)
Refractive Index 1.4303
pH 3.5 (1g/l, H2O)
Log P 1.57 at 25℃

How is Azelaic acid classified and handled safely? Learn More

Warning
GHS07· Irritant

Hazard Statements

H315 Causes skin irritation
H319 Causes serious eye irritation

Precautionary Statements

P264 Wash … thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P321 Specific treatment (see … on this label).
P264+P265 Wash … thoroughly after handling.

Which trade and regulatory codes apply to Azelaic acid?

HS Code 29171390
Storage Class 11 - Combustible Solids
WGK (Germany) 1
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