L-mandelic acid

L-mandelic acid (CAS 17199-29-0), also known as (S)-mandelic acid, is a chiral alpha-hydroxy acid used as a stereospecific building block and active ingredient in pharmaceutical and cosmetic manufacturing.

Where is L-mandelic acid used?

• Pharmaceutical synthesis: chiral intermediate for antibiotics
• Antispasmodics and other APIs requiring a single enantiomer for regulatory compliance
• Cosmetic exfoliants: peels, serums and toners
• It provides keratolytic action with gentler tolerance than glycolic acid.
• Topical antimicrobials: preservative and biocidal properties
• Specialty formulations: pH buffer and stabilizer without racemic impurities

Good to know: Its defined stereochemistry suits uses where enantiomeric purity is a critical specification. Not to be confused with glycolic acid, which has a harsher tolerance profile.

Commercial specifications

• Enantiomeric excess (ee%) is a standard quality parameter for pharma procurement