D-alanine

CAS Number
338-69-2
EC Number
206-418-1
Abbreviation
D-Ala

What is D-alanine?

D-Alanine (CAS 338-69-2), also known as D-Ala, is the D-enantiomer of the naturally occurring amino acid alanine.

Where is D-alanine used?

  • Pharmaceutical manufacturing: chiral intermediate
  • Synthesis of peptide antibiotics, enzyme inhibitors and other stereospecific active compounds
  • Cosmetics: moisturizing and pH-buffering properties in skin care
  • Food and nutrition: flavor modifier and stabilizer in specialty formulations, including amino acid-enriched dietary supplements
  • Research and peptide synthesis laboratories source it as a building block for custom peptide sequences requiring non-natural amino acid incorporation.

Good to know: Demand is driven primarily by its role in synthesizing peptide-based active ingredients and pharmaceutical intermediates where enantiomeric purity is critical.

Commercial specifications

  • Packaging from small quantities for laboratory and R&D use to bulk quantities for industrial peptide synthesis

Other Names (Synonyms)

(2R)-2-aminopropanoic acid|D-2-Aminopropionic acid|D-Ala|D-alpha-Alanine|Alanine, D-|Alanine D-form|(R)-2-Aminopropionic acid|Ba 2776

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What are the physical properties of D-alanine?

Melting Point 292 °C
Boiling Point 212.9±23.0 °C(Predicted)
Density 1.4310 (estimate)
Appearance White Crystalline Powder
Color White to off-white
Odor odorless
Form Crystalline Powder or Crystals
Water Solubility 155 g/L (20 ºC)
Refractive Index -14 ° (C=2, 6mol/L HCl)
Log P -0.574 (est)

How is D-alanine classified and handled safely? Learn More

Warning
GHS07· Irritant

Hazard Statements

H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation

Precautionary Statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Which trade and regulatory codes apply to D-alanine?

HS Code 29224900
Storage Class 11 - Combustible Solids
WGK (Germany) 3
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