Mandelic acid

Mandelic acid (CAS 90-64-2), also known as phenylglycolic acid, is an alpha-hydroxy acid derived from bitter almonds; it functions as a pharmaceutical intermediate, preservative, and skin-active ingredient.

Where is Mandelic acid used?

• Pharmaceutical manufacturing: chiral intermediate in synthesis of antibiotics, anticoagulants, and antispasmodics, with optical isomers resolved
• Cosmetic formulation: chemical peel systems and leave-on exfoliants, with larger molecular size than glycolic acid giving controlled skin penetration
• Preservative and pH buffer in urinary tract preparations and topical antimicrobial products
• Specialty resins and surface treatment: wetting and adhesion modifier
• It is suited to sensitive skin formulations.

Good to know: Its larger molecular size relative to glycolic acid allows a more controlled skin penetration profile, making it suited to sensitive skin formulations.