SoleChem

Acetylsalicylic acid

Flavors & Fragrances Food & Nutrition
CAS
50-78-2
EC
200-064-1
Mol. Weight
180.16 g/mol

Description

Acetylsalicylic acid (CAS 50-78-2) is a synthetic salicylate derivative used across pharmaceutical manufacturing, personal care formulation, and specialty chemical applications. It functions primarily as an active pharmaceutical ingredient and chemical intermediate.

In pharmaceutical manufacturing, ASA is the active ingredient in analgesic, antipyretic, and antiplatelet solid dosage forms. These include tablets, effervescent formulations, and coated pellets for various medical applications.

Personal care formulators incorporate it as a keratolytic and preservation-supporting agent in exfoliating creams and scalp treatments. It is also frequently utilized in the production of anti-dandruff products and skin care solutions.

As a chemical intermediate, it serves in the synthesis of salicylate-based compounds where controlled acetylation is required. This versatility makes it a staple in industrial chemical synthesis and laboratory research.

In food-contact and specialty applications, its antioxidant and mild acidulant properties support stabilization in defined regulatory frameworks. It plays secondary roles in preservation and pH-related formulation work across industries.

Acetylsalicylic acid is supplied as a white crystalline powder in pharmaceutical and technical grades. USP, BP, and Ph.Eur. specifications are standard for pharmaceutical procurement and quality assurance.

Particle size distribution is often specified for tableting or coating processes to ensure manufacturing efficiency. Bulk quantities are available for industrial buyers requiring consistent material for large-scale production runs.

Pharma-grade material typically requires full documentation including CoA and residual solvent profiles. This ensures compliance with global safety standards and rigorous quality control protocols for sensitive applications.

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Physical Properties

Melting Point 135 °C
Boiling Point 140 °C
Density 1.40 g/cm³
Flash Point 250 °C
Appearance Acetylsalicylic acid is a white crystalline solid with a slightly bitter taste. It is odorless but hydrolyzes in moist air to give an acetic acid odor
Color white
Form crystalline
Water Solubility 3.3 g/L (20 ºC)
Refractive Index 1.4500 (estimate)
Log P 1.190

Safety & Handling (Learn More)

Warning GHS07 GHS08
Hazard Statements
H302 Harmful if swallowed
H315 Causes skin irritation
H316 Causes mild skin irritation
H319 Causes serious eye irritation
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335 May cause respiratory irritation
H360 May damage fertility or the unborn child
H370 Causes damage to organs
H371 May cause damage to organs
H372 Causes damage to organs through prolonged or repeated exposure
H373 May causes damage to organs through prolonged or repeated exposure
H412 Harmful to aquatic life with long lasting effects
Precautionary Statements
P203 Obtain, consult and follow expert instructions for use.
P233 Keep container tightly closed.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 In case of inadequate ventilation wear respiratory protection.
P318 IF exposed or concerned, get medical advice.
P319 Get medical advice/attention if you feel unwell.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P403 Store in a well-ventilated place.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local regulations.
P264+P265 Wash … thoroughly after handling.
P301+P317 Get emergency medical help.
P302+P352 IF ON SKIN: Wash with plenty of water.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P308+P316 Get emergency medical help immediately.
P332+P317 Get emergency medical help.
P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P342+P316 Get emergency medical help immediately.
P362+P364 Take off contaminated clothing and wash it before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code 29182200
UN Number 1851
Storage Class 11 - Combustible Solids
WGK (Germany) 1

Documentation

Other Names

2-acetyloxybenzoic acid|Aspirin|ASA

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