5-chlorosalicylic acid

CAS Number
321-14-2
EC Number
206-283-9

What is 5-chlorosalicylic acid?

5-Chlorosalicylic acid (CAS 321-14-2), also referenced in procurement as 5-CSA, is an organochlorine derivative of salicylic acid used as a building block in pharmaceutical synthesis and as a functional additive in industrial formulations.

Where is 5-chlorosalicylic acid used?

  • Pharmaceutical manufacturing: key intermediate
  • Synthesis of antimicrobial and anti-inflammatory APIs, where controlled chlorination and hydroxyl positioning are critical to the final molecule's activity
  • Coating and resin formulators incorporate it as a UV stabilizer and antioxidant to extend the service life of protective coatings exposed to outdoor weathering
  • Adhesive and sealant systems: biocidal and preservation properties that inhibit microbial degradation
  • Personal care: preservative-boosting component in leave-on and rinse-off products where broad-spectrum efficacy is required

Commercial specifications

  • Technical and pharmaceutical-grade material; pharmaceutical-grade product typically meeting defined purity thresholds
  • Packaging ranges from kilogram-scale laboratory quantities to bulk drum supply

Other Names (Synonyms)

5-Chloro-2-hydroxybenzoic acid|5 CSA|2-Hydroxy-5-chlorobenzoic acid|Benzoic acid, 5-chloro-2-hydroxy-|Salicylic acid, 5-chloro-|J2YFG68VCZ

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What are the physical properties of 5-chlorosalicylic acid?

Melting Point 171.5 °C
Boiling Point 244.67°C (rough estimate)
Density 1.3766 (rough estimate)
Appearance OFF-WHITE TO CREAM POWDER
Color White to Almost white
Form powder to crystal
Water Solubility 1 g/L (20 ºC)
Refractive Index 1.4580 (estimate)
pH 2.5 (H2O, 20℃)(aqueous suspension)
Log P 3.090

How is 5-chlorosalicylic acid classified and handled safely? Learn More

Danger
GHS06· Toxic GHS07· Irritant

Hazard Statements

H301 Toxic if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation

Precautionary Statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.

Which trade and regulatory codes apply to 5-chlorosalicylic acid?

HS Code 29182990
UN Number 2811
ADR Class 6.1
Packing Group III
Storage Class 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
WGK (Germany) 3
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