2-chloronicotinic acid

CAS Number
2942-59-8
EC Number
220-937-0
Chemical Formula
C6H4ClNO2
Molecular Weight
157.55 g/mol

Description

2-Chloronicotinic acid (CAS 2942-59-8) is a halogenated pyridinecarboxylic acid used primarily as a building block in pharmaceutical synthesis and agrochemical manufacturing. Its reactive chloro and carboxylic acid groups make it a reliable intermediate for constructing more complex heterocyclic structures across multiple industries and chemical research applications.

In pharmaceutical development, it serves as a key intermediate in the synthesis of active pharmaceutical ingredients, particularly antiviral, antibacterial, and CNS-targeted compounds. Agrochemical formulators use it to produce herbicide and fungicide active substances, where the chloropyridine scaffold contributes significantly to the final biological activity.

In specialty chemical manufacturing, it functions as a precursor for flame retardant additives and catalyst components used in various types of polymer processing and stabilization. Personal care and textile applications draw on its reactivity for surface modification agents and preservation chemistry in formulated products requiring specific chemical stability.

This product is supplied as a white to off-white crystalline powder. Standard commercial offerings include technical grade and high-purity grades suitable for pharmaceutical intermediate use. Purity levels are typically at 98% or above confirmed by HPLC. Packaging ranges from small quantities for R&D procurement to bulk quantities for industrial-scale synthesis.

Other Names (Synonyms)

2-Chloropyridine-3-carboxylic acid|2-Chloro-3-pyridinecarboxylic acid|3-Pyridinecarboxylic acid, 2-chloro-|Nicotinic acid, 2-chloro-|3-Carboxy-2-chloropyridine|CNIS

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

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Physical Properties

Melting Point 194.00 °C
Boiling Point 316.8±22.0 °C(Predicted)
Density 1.470±0.06 g/cm3(Predicted)
Appearance White to cream powder
Color White to cream
Odor Pungent odor
Form Powder
Log P 0.988

Documentation

Safety & Handling Learn More

Warning
GHS07· Irritant

Hazard Statements

H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation

Precautionary Statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Trade & Regulatory

HS Code 29333999
Storage Class 11 - Combustible Solids
WGK (Germany) 3
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