4-chlorobutanoic acid
CAS Number
627-00-9
EC Number
210-975-2
Industries: Pharma & Healthcare
What is 4-chlorobutanoic acid?
4-Chlorobutanoic acid (CAS 627-00-9), also known as 4-chlorobutyric acid and gammachlorobutyric acid, is a halogenated organic acid used primarily as a building block in pharmaceutical synthesis.
Where is 4-chlorobutanoic acid used?
- Pharmaceutical manufacturing: key intermediate
- Biotechnology and life sciences: preparation of labeled compounds, linkers and probe molecules for drug discovery
- Agrochemical synthesis: halogenated acid intermediates for herbicide and pesticide active substances
- Its chloro group enables nucleophilic substitution reactions central to gamma-lactam and pyrrolidone ring systems.
Commercial specifications
- Liquid or low-melting solid depending on purity and storage conditions
- Technical and high-purity grades
- Packaging from small laboratory quantities to bulk quantities for industrial synthesis
Other Names (Synonyms)
4-chlorobutyric acid|Butanoic acid, 4-chloro-|Gammachlorobutyric acid|Cl(CH2)3COOH|.gamma.-Chloro-n-butyric acid|Butyric acid, 4-chloro-|γ-Chlorobutyric acid|4-CBA
What are the physical properties of 4-chlorobutanoic acid?
Melting Point 16 °C
Boiling Point 67-72 °C @ Press: 2.5 Torr
Density 1.2373 g/cm³ @ Temp: 20 °C
Flash Point >230 °F
Color Colorless to Almost colorless
Form clear liquid
Refractive Index n 20/D 1.451(lit.)
How is 4-chlorobutanoic acid classified and handled safely? Learn More
Danger
GHS05· Corrosive GHS07· Irritant
Hazard Statements
H302 H302
H314 H314
Precautionary Statements
P260 P260
P264 P264
P270 P270
P280 P280
Which trade and regulatory codes apply to 4-chlorobutanoic acid?
HS Code 29159000
UN Number 3265
ADR Class 8
Packing Group II
Storage Class 8A - Combustible corrosive hazardous materials
WGK (Germany) 3