3-cyanopyridine

CAS Number
100-54-9
EC Number
202-863-0
Abbreviation
3-CP

What is 3-cyanopyridine?

3-Cyanopyridine (CAS 100-54-9), also known as nicotinic acid nitrile and abbreviated 3-CP, is a pyridine-based nitrile intermediate.

Where is 3-cyanopyridine used?

  • Pharmaceuticals: building block for heterocyclic structures, vitamin B3 derivatives and active pharmaceutical ingredients
  • Pharmaceutical manufacturing: direct precursor to nicotinamide
  • Nicotinic acid production at industrial scale through controlled hydrolysis
  • Agrochemicals: intermediate in synthesizing pyridine-based pesticides and fungicides
  • Specialty chemicals: the nitrile group enables selective downstream functionalization
  • Flavor chemistry: contributes to compounds with roasted and meaty flavor profiles
  • Biotechnology and life sciences: reagent in catalyst development and substrate in enzymatic hydrolysis research
  • It serves as a substrate in enzymatic hydrolysis research targeting nitrile hydratase activity.

Commercial specifications

  • Purity levels typically range from 98% to 99%+ depending on the intended application.
  • Packaging options range from kilogram-scale laboratory quantities to multi-tonne bulk supply for industrial users.

Other Names (Synonyms)

3-azabenzonitrile|3-PYRIDINECARBONITRILE|Nicotinic acid nitrile|3-Pyridinenitrile|3-Pyridylcarbonitrile|Nitryl kwasu nikotynowego|3-Pyridinecarboxylic acid, nitrile|Pyridine-3-carbonitrile|3-CP

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What are the physical properties of 3-cyanopyridine?

Melting Point 51 °C
Boiling Point 206.9 °C
Density 1.1590 g/cm³ @ Temp: 25 °C
Flash Point 184 °F
Appearance The cyanopyridines are as follows: 2-cyano-: A white to tan liquid or solid. Almond odor. Boiling point=2213℃ ; freezing/melting point=27℃ ; flash point=89℃ . 3-cyano-: a colorless liquid or gray crystal- line solid.
Color Colorless or white to yellow
Form Crystalline Mass, Crystals or Chunks
Water Solubility 140 g/L (20 ºC)
Refractive Index 1.5242 (estimate)

How is 3-cyanopyridine classified and handled safely? Learn More

Warning
GHS05· Corrosive GHS07· Irritant GHS08· Health Hazard

Hazard Statements

H302 H302
H315 H315
H318 H318
H319 H319

Precautionary Statements

P260 P260
P261 P261
P264 P264
P270 P270

Which trade and regulatory codes apply to 3-cyanopyridine?

HS Code 29333999
Storage Class 11 - Combustible Solids
WGK (Germany) 3
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