4-methylpyridine

CAS Number
108-89-4
EC Number
203-626-4
Abbreviation
4-MP

What is 4-methylpyridine?

4-Methylpyridine (CAS 108-89-4) is a pyridine-based heterocyclic building block. Also known as p-picoline or gamma-picoline.

Where is 4-methylpyridine used?

  • Pharmaceuticals: precursor in the synthesis of isonicotinic acid derivatives and active pharmaceutical ingredients targeting cardiovascular and neurological conditions
  • Agrochemicals: manufacture of herbicides
  • Coatings and adhesives: curing catalyst and crosslinking accelerator for epoxy systems, influencing cure rate and final film performance
  • It functions primarily as a reactive intermediate and catalyst.

Good to know: At trace concentrations, it contributes roasted and nutty flavor notes in food applications, with usage governed by FEMA-recognized flavor standards.

Commercial specifications

  • Liquid at standard commercial purities, typically 98% and 99%+ grades for pharmaceutical and synthesis applications
  • Packaging ranges from drums to ISO tank quantities
  • USP and FCC standards where applicable for specific high-purity industrial needs

Other Names (Synonyms)

p-picoline|p-methylpyridine|gamma-picoline|4-picoline|4-Mepy|Pyridine, 4-methyl-|gamma-Methylpyridine|Ba 35846|4-MP

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What are the physical properties of 4-methylpyridine?

Melting Point 3.66 °C
Boiling Point 145 °C @ Press: 760 Torr
Density 0.9548 g/cm³ @ Temp: 20 °C
Flash Point 134 °F
Appearance Picolines are colorless liquids. Strong, unpleasant, pyridine-like odor.“Picoline” is often used as mixed isomers.
Color Clear light yellow
Odor Obnoxious, Sweetish
Form Liquid
Water Solubility soluble
Vapor Pressure 4 mm Hg ( 20 °C)
Refractive Index n 20/D 1.504(lit.)
Log P 1.22 at 25℃

How is 4-methylpyridine classified and handled safely? Learn More

Danger
GHS02· Flammable GHS06· Toxic GHS07· Irritant GHS08· Health Hazard

Hazard Statements

H226 H226
H302 H302
H311 H311
H315 H315

Precautionary Statements

P210 P210
P233 P233
P240 P240
P241 P241

Which trade and regulatory codes apply to 4-methylpyridine?

HS Code 29333955
UN Number 1992
ADR Class 3
Packing Group III
Storage Class 3 - Flammable liquids
WGK (Germany) 1
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