Amines REACH

2-methylpyridine

CAS Number
109-06-8
EC Number
203-643-7

What is 2-methylpyridine?

2-Methylpyridine (CAS 109-06-8), commercially known as alpha-picoline, is a nitrogen-containing heterocyclic compound used as a key building block in pharmaceutical synthesis, agrochemical production, and specialty chemical manufacturing.

Where is 2-methylpyridine used?

  • Pharmaceuticals: precursor to vinylpyridine derivatives
  • Production of antihistamines and vitamins including B6 and melatonin-related compounds
  • Agrochemicals: synthesis of herbicides and insecticides, particularly chloropyrifos-related intermediates
  • Flavor and fragrance: synthesis of aroma compounds exploiting methyl-group reactivity
  • Catalyst or co-solvent
  • It is utilized in resin and polymer production.

Commercial specifications

  • Technical grade predominant, purity typically 99% or higher confirmed by GC analysis
  • Material adhering to USP or BP standards
  • Liquid in standard industrial drum and IBC quantities, with bulk tanker options

Other Names (Synonyms)

alpha-picoline|a-Picoline|2-Picoline|o-Picoline|Pyridine, 2-methyl-|alpha-Methylpyridine|o-Methylpyridine|PICOLINE, ALPHA

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What are the physical properties of 2-methylpyridine?

Melting Point -70 °C
Boiling Point 128-129 °C
Density 0.9443 g/cm³ @ Temp: 20 °C
Flash Point 79 °F
Appearance Picolines are colorless liquids. Strong, unpleasant, pyridine-like odor.“Picoline” is often used as mixed isomers.
Color Clear pale yellow
Odor Unpleasant
Form Liquid
Water Solubility MISCIBLE
Vapor Pressure 10 mm Hg ( 24.4 °C)
Refractive Index n 20/D 1.500(lit.)
pH 8.5 (100g/l, H2O, 20℃)
Log P 1.11 at 20℃

How is 2-methylpyridine classified and handled safely? Learn More

Danger
GHS02· Flammable GHS07· Irritant GHS05· Corrosive GHS06· Toxic GHS08· Health Hazard

Hazard Statements

H226 H226
H302 H302
H311 H311
H312 H312

Precautionary Statements

P203 P203
P210 P210
P233 P233
P240 P240

Which trade and regulatory codes apply to 2-methylpyridine?

HS Code 29333999
UN Number 2313
ADR Class 3
Packing Group III
Storage Class 3 - Flammable liquids
WGK (Germany) 1
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