3-picoline
Description
3-Picoline (CAS 108-99-6), also known as beta-picoline, is a methylpyridine isomer used primarily as a chemical intermediate in the synthesis of vitamins, agrochemicals, and pharmaceutical actives.
It serves as a building block rather than a finished ingredient, making it a procurement priority for manufacturers operating upstream in their supply chains across various industrial sectors.
In the pharmaceutical and nutrition industries, this compound is the principal precursor for nicotinamide (Vitamin B3) and nicotinic acid synthesis, ensuring high-quality output for global health markets.
Agrochemical producers use it to manufacture pyridine-based herbicides and insecticides, particularly in active ingredient synthesis where chemical stability and reactivity are essential for performance.
In flavor chemistry, trace concentrations contribute roasted, nutty, or meaty notes to processed food formulations, while resin formulators employ it as a catalyst in select polymerization processes.
The material is supplied as a liquid in bulk quantities, typically in drums or ISO tank containers for large-volume orders to meet the logistical needs of global chemical manufacturing facilities.
Technical-grade material is the standard commercial offering, with purity levels commonly at 99% or higher by GC, ensuring consistent results in standard industrial applications and chemical reactions.
Pharmaceutical-grade specifications are available from select manufacturers where downstream API synthesis demands tighter impurity profiles and adherence to rigorous quality control protocols during production.
Physical Properties
| Melting Point | -18.1 °C |
| Boiling Point | 143-144 °C |
| Density | 0.9566 g/cm³ @ Temp: 20 °C |
| Flash Point | 97 °F |
| Appearance | Picolines are colorless liquids. Strong, unpleasant, pyridine-like odor.“Picoline” is often used as mixed isomers. |
| Color | Clear yellow |
| Odor | Unpleasant |
| Form | Liquid |
| Water Solubility | soluble |
| Vapor Pressure | 4.4 mm Hg ( 20 °C) |
| Refractive Index | n 20/D 1.504(lit.) |
| pH | 10 (100g/l, H2O, 20℃) |
| Log P | 1.2 at 20℃ |
Safety & Handling (Learn More)
Trade & Regulatory
| HS Code | 29333999 |
| UN Number | 2313 |
| ADR Class | 3 |
| Packing Group | III |
| Storage Class | 3 - Flammable liquids |
| WGK (Germany) | 1 |
Documentation
Other Names
beta-picoline|b-Picoline|3-methylpyridine|Pyridine, 3-methyl-|m-Picoline|m-Methylpyridine|beta-Methylpyridine|B083J4KF7F
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