3-picoline
CAS Number
108-99-6
EC Number
203-636-9
What is 3-picoline?
3-Picoline (CAS 108-99-6), also known as beta-picoline, is a methylpyridine isomer used primarily as a chemical intermediate in the synthesis of vitamins, agrochemicals, and pharmaceutical actives.
Where is 3-picoline used?
- Pharmaceutical and nutrition: principal precursor for nicotinamide (Vitamin B3) and nicotinic acid synthesis
- Agrochemicals: manufacture of pyridine-based herbicides and insecticides
- Flavor chemistry: trace concentrations contribute roasted, nutty, or meaty notes to processed food formulations
- Resin formulators employ it as a catalyst in select polymerization processes.
Commercial specifications
- Technical grade: purity commonly 99% or higher by GC
- Pharmaceutical grade available from select manufacturers for tighter impurity profiles
- Liquid in bulk quantities, typically drums or ISO tank containers
Other Names (Synonyms)
beta-picoline|b-Picoline|3-methylpyridine|Pyridine, 3-methyl-|m-Picoline|m-Methylpyridine|beta-Methylpyridine|B083J4KF7F
What are the physical properties of 3-picoline?
Melting Point -18.1 °C
Boiling Point 143-144 °C
Density 0.9566 g/cm³ @ Temp: 20 °C
Flash Point 97 °F
Appearance Picolines are colorless liquids. Strong, unpleasant, pyridine-like odor.“Picoline” is often used as mixed isomers.
Color Clear yellow
Odor Unpleasant
Form Liquid
Water Solubility soluble
Vapor Pressure 4.4 mm Hg ( 20 °C)
Refractive Index n 20/D 1.504(lit.)
pH 10 (100g/l, H2O, 20℃)
Log P 1.2 at 20℃
How is 3-picoline classified and handled safely? Learn More
Danger
GHS02· Flammable GHS05· Corrosive GHS06· Toxic GHS07· Irritant GHS08· Health Hazard GHS09· Environmental Hazard
Hazard Statements
H226 H226
H302 H302
H311 H311
H314 H314
Precautionary Statements
P203 P203
P210 P210
P233 P233
P240 P240
Which trade and regulatory codes apply to 3-picoline?
HS Code 29333999
UN Number 2313
ADR Class 3
Packing Group III
Storage Class 3 - Flammable liquids
WGK (Germany) 1