Amines
REACH
Pyrrolidine
CAS Number
123-75-1
EC Number
204-648-7
FEMA Number
FEMA 3523
What is Pyrrolidine?
Pyrrolidine (CAS 123-75-1), also known as Azolidine, is a saturated five-membered nitrogen heterocycle. FEMA 3523.
Where is Pyrrolidine used?
- Food and flavor manufacturing: production of thermally derived flavor compounds contributing roasted, grain, and savory notes to processed foods and beverages
- Pharmaceutical: key synthetic intermediate for APIs, with the pyrrolidine ring incorporated into drug candidates
- Personal care: synthesis of conditioning agents and specialty amines for hair and skin formulations
- Agrochemical: intermediate in fungicide and pesticide synthesis
- It functions as a building block for synthesizing active ingredients and flavor compounds.
Good to know: Buyers should confirm purity specifications and moisture content with suppliers, as grade requirements vary significantly by end use. Material quality is often verified against internal manufacturer specifications or recognized standards such as USP, Ph. Eur., BP, EP, FCC, or ACS depending on the specific grade and application.
Commercial specifications
- Technical and reagent grades commonly available for industrial and laboratory procurement
- High-purity pharmaceutical-grade material offered for API synthesis
Other Names (Synonyms)
Azolidine|Prolamine|1-Azacyclopentane|Pyrrole, tetrahydro-|2-Imidazolidone
What are the physical properties of Pyrrolidine?
Melting Point -63 °C
Boiling Point 86.71 °C
Density 0.8520 g/cm³ @ Temp: 22.5 °C
Flash Point 37 °F
Appearance colourless to pale yellow liquid with a penetrating
Color Colorless to Almost colorless
Odor at 0.10 % in propylene glycol. ammoniacal animal egg amine
Form Liquid
Water Solubility Miscible with alcohol, ether, chloroform and water.
Vapor Pressure 128 mm Hg ( 39 °C)
Refractive Index n 20/D 1.443(lit.)
pH 12.9 (100g/l, H2O, 20℃)
Log P 0.22 at 25℃
How is Pyrrolidine classified and handled safely? Learn More
Danger
GHS02· Flammable GHS05· Corrosive GHS07· Irritant GHS06· Toxic GHS08· Health Hazard
Hazard Statements
H225 Highly Flammable liquid and vapor
H301 Toxic if swallowed
H302 Harmful if swallowed
H314 Causes severe skin burns and eye damage
Precautionary Statements
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment.
Which trade and regulatory codes apply to Pyrrolidine?
HS Code 29339900
UN Number 1922
ADR Class 3
Packing Group II
Storage Class 3 - Flammable liquids
WGK (Germany) 2