Amines REACH

Pyrrolidine

CAS Number
123-75-1
EC Number
204-648-7
Chemical Formula
C4H9N
Molecular Weight
71.12 g/mol
FEMA Number
FEMA 3523

Description

Pyrrolidine (CAS 123-75-1), also known as Azolidine, is a saturated five-membered nitrogen heterocycle used as a flavoring agent and chemical intermediate across food, pharmaceutical, and personal care industries. Assigned FEMA 3523, it functions as a building block for synthesizing active ingredients and flavor compounds rather than as a finished additive in its own right for most industrial applications.

In food and flavor manufacturing, it is used to produce thermally derived flavor compounds that contribute roasted, grain, and savory notes to processed foods and beverages during the production cycle. Pharmaceutical formulators rely on it as a key synthetic intermediate for APIs, where the pyrrolidine ring is incorporated into drug candidates targeting a range of therapeutic categories and medical needs.

In personal care, it supports the synthesis of conditioning agents and specialty amines used in hair and skin formulations. Agrochemical producers also use it as an intermediate in fungicide and pesticide synthesis. Pyrrolidine is supplied as a colorless to pale yellow liquid in standard drum and IBC packaging. Technical and reagent grades are the most commonly available for industrial and laboratory procurement needs.

High-purity pharmaceutical-grade material is offered for API synthesis applications. Buyers should confirm purity specifications and moisture content with suppliers, as grade requirements vary significantly by end use. Material quality is often verified against internal manufacturer specifications or recognized standards such as USP, Ph.Eur., BP, EP, FCC, or ACS depending on the specific grade and application.

Other Names (Synonyms)

Azolidine|Prolamine|1-Azacyclopentane|Pyrrole, tetrahydro-|2-Imidazolidone

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

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Physical Properties

Melting Point -63 °C
Boiling Point 86.71 °C
Density 0.8520 g/cm³ @ Temp: 22.5 °C
Flash Point 37 °F
Appearance colourless to pale yellow liquid with a penetrating
Color Colorless to Almost colorless
Odor at 0.10 % in propylene glycol. ammoniacal animal egg amine
Form Liquid
Water Solubility Miscible with alcohol, ether, chloroform and water.
Vapor Pressure 128 mm Hg ( 39 °C)
Refractive Index n 20/D 1.443(lit.)
pH 12.9 (100g/l, H2O, 20℃)
Log P 0.22 at 25℃

Documentation

Safety & Handling Learn More

Danger
GHS02· Flammable GHS05· Corrosive GHS07· Irritant GHS06· Toxic GHS08· Health Hazard

Hazard Statements

H225 Highly Flammable liquid and vapor
H301 Toxic if swallowed
H302 Harmful if swallowed
H314 Causes severe skin burns and eye damage

Precautionary Statements

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment.

Trade & Regulatory

HS Code 29339900
UN Number 1922
ADR Class 3
Packing Group II
Storage Class 3 - Flammable liquids
WGK (Germany) 2
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