4-cyanopyridine

CAS Number
100-48-1
EC Number
202-856-7
Abbreviation
4-CP

What is 4-cyanopyridine?

4-Cyanopyridine (CAS 100-48-1), also known as isonicotinic acid nitrile and abbreviated as 4-CP, is a pyridine-based nitrile building block.

Where is 4-cyanopyridine used?

  • Pharmaceutical manufacturing: precursor in the synthesis of antifungal agents, antivirals, and other nitrogen-containing active pharmaceutical ingredients
  • Agrochemicals: building block for pyridine-derived herbicides and fungicides
  • Ligands and coordination complexes: catalysts or catalyst precursors in organometallic chemistry and advanced material science
  • Flavor chemistry: contributes to select fragrance and flavor compound synthesis
  • It functions as a reactive intermediate, enabling the construction of more complex heterocyclic structures through its dual nitrile and pyridine functionalities.

Commercial specifications

  • Standard commercial grades include technical and high-purity specifications
  • Packaging typically ranges from kilogram-scale to bulk orders

Other Names (Synonyms)

4-Pyridinecarbonitrile|pyridine-4-carbonitrile|Isonicotinic acid nitrile|BY3226D010|γ-Cyanopyridine|p-Cyanopyridine|4-CP

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What are the physical properties of 4-cyanopyridine?

Melting Point 79 °C
Boiling Point 78 °C @ Press: 6 Torr
Density 1.1145 (rough estimate)
Flash Point 88 °C
Appearance The cyanopyridines are as follows: 2-cyano-: A white to tan liquid or solid. Almond odor. Boiling point=2213℃ ; freezing/melting point=27℃ ; flash point=89℃ . 3-cyano-: a colorless liquid or gray crystal- line solid.
Color White to off-white
Form Crystals or Powder
Water Solubility 3.2 g/100ml (16.4 ºC)
Vapor Pressure 41.9Pa at 25℃
Refractive Index 1.5242 (estimate)
Log P 0.46 at 25℃

How is 4-cyanopyridine classified and handled safely? Learn More

Warning
GHS07· Irritant

Hazard Statements

H302 H302
H312 H312
H319 H319
H332 H332

Precautionary Statements

P261 P261
P264 P264
P270 P270
P271 P271

Which trade and regulatory codes apply to 4-cyanopyridine?

HS Code 29333999
Storage Class 11 - Combustible Solids
WGK (Germany) 3
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