P-tolunitrile

CAS Number
104-85-8
EC Number
203-244-8

What is P-tolunitrile?

P-tolunitrile (CAS 104-85-8), also known as 4-cyanotoluene, is an aromatic nitrile compound used as a chemical intermediate in the synthesis of active ingredients and specialty chemicals.

Where is P-tolunitrile used?

  • Pharmaceutical synthesis: precursor to active pharmaceutical ingredients
  • Fragrance manufacturing: intermediate in production of aromatic compounds where controlled functionalization is required
  • Agrochemical production: contributes to synthesis of herbicides and fungicides through established nitrile chemistry pathways
  • Industrial cleaning and biocide formulations may incorporate derivatives produced from this intermediate.

Good to know: Buyers should confirm purity specifications and impurity profiles directly with the supplier. The material is handled according to standard industrial safety protocols for aromatic nitriles.

Commercial specifications

  • Purity grades typically ranging from technical to high-purity for pharmaceutical and specialty chemical applications
  • Standard packaging configurations including drums and intermediate bulk containers suited to industrial procurement volumes

Other Names (Synonyms)

4-METHYLBENZONITRILE|4-Cyanotoluene|4-Tolunitrile|p-Methylbenzonitrile|Benzonitrile, 4-methyl-|p-Cyanotoluene|p-Toluonitrile|p-Tolylnitrile

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What are the physical properties of P-tolunitrile?

Melting Point 29.5 °C
Boiling Point 220 °C
Density 0.981 g/mL at 25 °C(lit.)
Flash Point 185 °F
Appearance beige solid
Color Clear
Form Viscous Liquid
Water Solubility <0.1 g/100 mL at 17 ºC
Refractive Index 1.5285-1.5305

How is P-tolunitrile classified and handled safely? Learn More

Danger
GHS07· Irritant GHS08· Health Hazard

Hazard Statements

H315 Causes skin irritation
H319 Causes serious eye irritation
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335 May cause respiratory irritation
H412 Harmful to aquatic life with long lasting effects

Precautionary Statements

P233 Keep container tightly closed.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.

Which trade and regulatory codes apply to P-tolunitrile?

HS Code 29269095
Storage Class 11 - Combustible Solids
WGK (Germany) 2
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